可疑原发性房角关闭激光干预后眼生物测量参数变化：5年随访研究  

Long term changes in biometric parameters of eye with primary angle closure suspect after laser peripheral iridotomy

作　　者：郭黎霞[1] 梁远波[2] 牟大鹏[3] 吕爱国[1] 李思珍[4] 张新[1] 范肃洁[1] Guo Lixia Liang Yuanbo Mu Dapeng Lv Aiguo Li Sizhen Zang Xin Fan Sujie(Handan Eye Hospital, Hebei 056001, China The Affiliated Eye Hospital, School of Ophthalmology and optometry, Wenzhou Medical University, Wenzhou 325027,China Beijing Ophthalmology ＆ Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China Nanjing Aier Eye Hospital, Nanjing 210006, China.)

机构地区：[1]邯郸市眼科医院(邯郸市第三医院),邯郸056001 [2]温州医科大学附属眼视光医院,温州325027 [3]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科学与视觉科学重点实验室,北京100730 [4]南京爱尔眼科医院,南京210006

出　　处：《中国实用眼科杂志》2017年第6期572-575,共4页Chinese Journal of Practical Ophthalmology

基　　金：河北省科技攻关项目（06276102D-61）

摘　　要：目的探讨可疑原发性房角关闭（PACS）患者激光周边虹膜切除术（LPI）后眼生物测量参数远期变化。方法前瞻性随机对照研究。河北省邯郸市眼科医院随访5年40例PACS患者，每例随机选取一眼行LPI治疗（激光组），另一眼观察（对照组）。术前及术后1年、5年进行眼科常规检查及A超眼生物测量，包括中央前房深度、晶状体厚度、眼轴长度。结果激光组自身比较，术后1年的中央前房深度较术前加深，但随着观察时间延长，中央前房深度逐渐变浅，术后5年低于术前，差异均有统计学意义（F=4.157，P 〈0.05）。与对照组相比，激光组术后1、5年的中央前房深度均大于对照组，差异有统计学意义（P 〈0.05）；且术后5年的中央前房深度的总下降值，也小于对照组（t=2.95，P 〈0.05）。两组的晶状体厚度逐渐增加，差异有统计学意义（P 〈0.05）。结论LPI能加深中央前房深度，能延缓中央前房变浅。Objective To quantitatively evaluate the long-term changes in biometric characteristics parameters after laser peripheral iridotomy （LPI） in primary angle closure suspect （PACS）. Methods A prospective case series study. 40 PACS patients in Handan Eye Hospital, Hebei were enrolled in five years. LPI was performed in one eye selected randomly of every case （LPI group）, the other was as naturally control eye. Routine ophthalmic tests and A-scan examination were performed on both eyes at presentation. 1 year and 5 year after LPI, including central anterior chamber depth （CACD）,lens thickness （LT） and axial length （AL） . Results Compared to before LPI, CACD was significantly deeper at 1 year, but more shallow at 5 year （all P〈0.05）. CACD in LPI group was more deeper than that in control group at 1 year, 5 year（P〈0.05）. Within 5 years , CACD was grad- ually decreased, but the CACD at 5 year in the laser group was still bigger than that in the control group （P〈0.05）. LT in both team were thick gradually within 5 years（P〈0.05）. Conclusions LPI can significantly deepen the central anterior chamber and delay the central anterior chamber shallow in PACS.

关 键 词：可疑原发性房角关闭 激光周边虹膜切除术 晶状体 

分 类 号：R775.2[医药卫生—眼科]