^(99m)Tc-GSA肝受体显像在肝功能评估临床研究应用及进展  

Clinical application of ^(99m)Tc-GSA in assessment of liver function by hepatic receptor imaging

作　　者：王荣福[1] 庞小溪 刘敏[1] 霍焱[1] Rong-Fu Wang Xiao-Xi Pang Min Liu Yan Huo(Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China)

机构地区：[1]北京大学第一医院核医学科,北京市100034

出　　处：《世界华人消化杂志》2017年第21期1903-1909,共7页World Chinese Journal of Digestology

基　　金：国家重大科学仪器设备开发专项基金资助项目;No.2011YQ03011409;十二五国家支撑计划基金资助项目;No.2014BAA03B03~~

摘　　要：我国是肝病大国,各种肝病严重影响人民健康,手术是多种肝病的重要治疗手段之一.术前肝功能评估对于手术方案制定发挥极为重要价值,其中尤以三维定量肝功能成像技术备受临床关注.近年来分子影像突飞猛进,恰巧这也是核医学分子影像技术的优势所在.大量研究证实新型肝细胞去唾液酸糖蛋白受体显像剂^(99m)Tc-半乳糖基人血清白蛋白(^(99m)Tc-galactosyl-human serum albumin,^(99m)Tc-GSA)能够于无创条件下较为准确地反映肝功能状态,但现有研究尚处于初始阶段,仍待深入的临床研究.本文旨在系统阐述^(99m)Tc-GSA单光子发射计算机断层成像肝受体显像基础上,结合已有临床研究及新进展,探索其潜在临床应用前景及未来发展动向.Liver disease is quite common in China, having a serious influence on the health of people. Surgery is still one of the most treatments for liver disease. Evaluation of liver function before operation plays an essential role in therapeutic scheme formulation, and preoperative 3D quantitative hepatic function imaging has attracted surgeons＇ attention. Molecular imaging technique is booming in recent years, especially in the field of nuclear medicine. As a novel ASGPR tracer, ^（99m）Tc-galactosyl-human serum albumin（^（99m）Tc-GSA） could accurately reflect liver function in a non-invasive manner. However, most of available studies remain at their primary stage, especially in China, and further clinical trials are required. In this paper, we will give a systematic introduction of hepatic receptor imaging by ^（99m）Tc-GSA single photon emission computed tomography scanning and discuss its potential clinical prospects.

关 键 词：99mTc-GSA 单光子发射计算机断层成像 肝功能 肝切除 

分 类 号：R575[医药卫生—消化系统] R817.4[医药卫生—内科学]