瑞舒伐他汀联合参麦注射液治疗AMI患者临床疗效及对血清YKL-40NF—κB水平和免疫功能的影响  

Influence on the levels of YKL - 40 NF - κB and analysis of the clinical effects for the patients with acute myocardial infarction by rosuvastatin with local injection shenmal injection

作　　者：刘丹[1] 李杰[1] 李浩[1] 涂清鲜 何成龙[1] 

机构地区：[1]遵义市第一人民医院心血管内科,贵州遵义563000

出　　处：《中国急救医学》2017年第8期705-708,共4页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨瑞舒伐他汀联合参麦注射液治疗急性心肌梗死（AMI）的临床疗效及对血清甲壳质酶蛋白40（YKL-40）、核因子-κB（NF—κB）水平，以及免疫功能的影响。方法按照随机数字表法将168例AMI患者分为瑞舒伐他汀组、参麦注射液组、联合组和对照组（每组各42例）。对照组给予常规综合治疗，瑞舒伐他汀组在对照组基础上给予瑞舒伐他汀钙片治疗，参麦注射液组在对照组基础上给予参麦注射液治疗，联合组在对照组基础上给予瑞舒伐他汀钙片＋参麦注射液治疗，比较各组治疗效果及相关指标变化情况。结果联合组患者疗程结束时总有效率明显高于对照组、参麦注射液组和瑞舒伐他汀组（P〈0．05）；联合组患者血清YKL-40、NF—κB、白细胞介素-6（IL-6）、高敏C-反应蛋白（hs—CRP）、肌酸激酶同工酶（CK—MB）、基质金属蛋白酶-9（MMP-9）、肌钙蛋白T（cTnT）水平均明显低于对照组、参麦注射液组和瑞舒伐他汀组（P〈0．05）。结论瑞舒伐他汀联合参麦注射液治疗AMI临床效果明显，可有效地改善YKL-40、NF—κB和炎症因子水平，调节免疫功能，减轻心肌损伤，推广价值较高。Objective To explore the influence on the levels of YKL -40, NF - κB and analysis of the clinical effects for the patients with acute myocardial infarction by rosuvastatin ＋ local injection shenmai injection. Methods 168 cases of patients with acute myocardial infarction were randomly divided into rosuvastatin group （42 cases）, local injection shenmai injection group （42 cases）, combination group （42 cases） and control group （42 cases）. The patients in control group were treated by routine comprehensive treatment; the patients in rosuvastatin group were treated by rosuvastatin based on control group; the patients in local injection shenmai injection group were treated by local injection shenmai injection based on control group; the patients in combination group were treated by rosuvastatin ＋ local injection shenmai injection based on control group. The clinical effects and related indicators were compared. Results The total effective rate for the combination group were higher than the control group, rosuvastatin group and local injection shenmai injection group （P 〈 0.05 ） ; The levels of YKL - 40, NF - κB, IL - 6, hs - CRP, CK - MB, MMP - 9 and cTnT for the combination group were lower than the control group, rosuvastatin group and local injection shenmai injection group （P 〈 0.05）. Conclusion It has good clinical effects for the patients with acute myocardial infarction by rosuvastatin ＋ local injection shenmai injection, it can improve the levels of YKL - 40, NF - κB,inflammation, regulating immune function, reduce the myocardial injury, it has high values of clinical extension.

关 键 词：急性心肌梗死(AMI) 瑞舒伐他汀钙片 参麦注射液 甲壳质酶蛋白40(YKL-40) 核因子-κB(NF—κB) 

分 类 号：R574.620.5[医药卫生—消化系统]