舒必利与莫沙必利治疗功能性消化不良的临床研究  

Clinical study of sulpiride and mosapride in treating patients with functional dyspepsia

作　　者：王二嫚[1] 朱祖明[1] 王建宁[1] 汪胜林[1] WANG Er - man ZHU Zu - ruing WANG Jian - ning et al(JiangningHospital of Nanjin)

机构地区：[1]南京市江宁医院消化内科,江苏南京211100

出　　处：《吉林医学》2017年第8期1462-1464,共3页Jilin Medical Journal

摘　　要：目的:观察舒必利与莫沙必利治疗功能性消化不良患者的临床疗效和安全性。方法:选取消化科门诊就诊的符合罗马Ⅲ诊断标准的100例FD患者,随机分配入舒必利组和莫沙必利组,舒必利组患者每日早餐前半小时服用舒必利(100 mg)治疗,莫沙必利组每日口服3次莫沙必利(5 mg)治疗。入组时和治疗4周后分别测量消化不良积分、水负荷试验(water load test,WLT)、HAMA及HAMD并记录治疗期间和治疗后不良反应发生情况。结果:舒必利组4例女性患者因泌乳停药,共96例患者完成研究,其中舒必利组46例,莫沙必利组50例。治疗4周后,两组上消化道症状评分均较治疗前显著降低,舒必利组改善幅度优于莫沙必利组,差异有统计学意义(P<0.05);治疗后两组WLT均有明显改善,其中舒必利组改善幅度明显优于莫沙必利组有效率90.2%,差异有统计学意义(P<0.05)。治疗组合并精神心理障碍者HAMA、HAMD评分改善幅度均优于莫沙必利组,差异有统计学意义(P<0.05)。结论:舒必利及莫沙必利均可明显改善功能性消化不良患者的临床症状,并能一定程度的改善胃的容受性舒张功能,舒必利治疗效果优于莫沙必利,可能与舒必利的情绪改善作用有关,但个别女性可能出现泌乳素升高。Objective To observe the efficacy and safety of sulpiride and mosapride in treating patients with functional dyspepsia. Method 100 patients diagnosed with functional dyspepsia according to Rome Ⅲ at the Division of Gastroenterology and Hepatology,Jiang Ning Hospital were recruited in this study. Patients were randomly given mosapride（ 5 mg,30 minutes before meal） or sulpiride（ 100 mg,30 minutes before breakfast） for 4 weeks. Dyspepsia score,WLT,HAMA and HAMD were used to measure the efficacy of tratment at baseline and after 4 weeks of treatment. Adverse events were recorded during and after treatment course. Results Four females in sulpiride group manifested lactation and sulpiride was ceased. 96 patients accomplished the trial. At the end of the trial,the upper gastrointestinal symptom scores of the two groups were significantly decreased,and the improvement was more significant in sulpiride group（ P〈0. 05）. The WLT of the two groups improved significantly. The improvement rate of the sulpiride group was better than 90. 2% of the mosapride group（ P〈0. 05）. The improvement of WLT,HAMA and HAMD scores was superior to Mosapride in patients with psychosocial disorder（ P〈0. 05）. Conclusion Both sulpiride and mosapride can improve the clinical symptoms of patients with functional dyspepsia and can improve the receptive diastolic function of the stomach. The effect of sulpiride is better than mosapride,which may be related to the effect of sulpiride on mood improvement. But prolactin-related reactions may occur in individual females.

关 键 词：功能性消化不良 舒必利 莫沙必利 

分 类 号：R57[医药卫生—消化系统]