乳腺癌患者中医体质与化疗性恶心呕吐的相关性研究  

Study on Correlation Between Chinese Medicine Constitution of Patients with Breast Cancer and Chemotherapy-Induced Nausea and Vomiting

作　　者：陈韵菲 刘昳[2] 孙烨[2] 蔡云[2] 王锐[2] 韩萍萍[2] 张哲[2] 王瑞[2] 叶峰[2] 

机构地区：[1]北京甘家口社区卫生服务中心,北京100037 [2]西安交通大学第一附属医院中医科,陕西西安710061

出　　处：《新中医》2017年第8期114-117,共4页New Chinese Medicine

基　　金：国家自然科学基金资助项目(81202672);陕西省中医药管理局基金项目(JC26)

摘　　要：目的 :分析原发性乳腺癌患者中医体质因素与化疗性恶心呕吐(CINV)发生的相关性。方法 :术后首次行辅助化疗的乳腺癌患者共306例,化疗全疗程结束后回收有效病例291例。首次化疗前应用《中医九种基本体质分类量表》进行调查,并对患者的中医体质类型、体质倾向进行分类诊断。化疗结束后记录每例患者整个疗程中CINV分度的最高级别。采用SPSS16.0进行统计分析。结果:五类化疗方案(CAF/FEC、TA/TE、AC/EC、TAC/TEC及NP/TEP/TP/CMF)的CINV发生率比较,差异无统计学意义(P>0.05)。气郁倾向患者CINV的0~Ⅱ度及Ⅲ~Ⅳ度发生率比较,差异有统计学意义(P<0.05);其余各种体质倾向CINV发生率比较,差异均无统计学意义(P>0.05)。气郁质患者CINV的0~Ⅱ度及Ⅲ~Ⅳ度发生率比较,差异有统计学意义(P<0.05);平和倾向患者CINV的0~Ⅱ度及Ⅲ~Ⅳ度发生率比较,差异有统计学意义(P<0.05)。其余各种体质类型CINV发生率比较,差异均无统计学意义(P>0.05)。结论:气郁体质、气郁倾向均是Ⅲ~Ⅳ度CINV发生的危险因素,随着气郁分值的增高,发生Ⅲ~Ⅳ度CINV的几率增大。Objective. To analyze the correlation between Chinese medicine constitution of patients with breast cancer and chemotherapy-induced nausea and vomiting（CINV）. Methods： There are 306 cases of patients with breast cancer who received the first adjuvant chemotherapy after operation, and 291 effective cases were collected when the course of chemotherapy was over. Before the first time of chemotherapy, conducted a survey by applying Nine Basic Types of Constitution in Chinese Medicine Questionnaire. Classified and diagnosed the Chinese medicine constitution types and constitutional tendency of patients. After chemotherapy, recorded the highest level of CINV during the whole course in each patient, and analyzed the results by SPAA16.0. Results, Compared the incidence of CINV of five chemotherapy regimens （CAF/FEC, TA/TE, AC/EC, TAC/TEC, and NP/TEP/TP/CMF） , there was no significance in differences （P〉0.05）. Compared the incidence of 0- Ⅱ degree and Ⅲ -Ⅳ degree of CINV in patients with tendency of qi stagnation, the difference was significant （P〈0.05） ; compared the incidence of CINV in other constitutional tendencies, there was no significance being found in differences （P〉 0.05）. Compared the incidence of 0- Ⅱ degree and Ⅲ -Ⅳdegree of CINV in patients with constitution of qi stagnation, the difference being significant （P〈 0.05）. Compared the incidence of 0- Ⅱ degree and III -IV degree of CINV in patients with balanced tendency, the difference being significant （P〈0.05）. Compared the incidence of CINV in other constitution types, there was no significance being found in differences （P〉 0.05）. Conclusion： The constitution of qi stagnation and tendency of qi stagnation are risk factors of the incidence of Ⅲ -Ⅳ degree of CINV. As the score of qi stagnation increases, the incidence of Ⅲ -Ⅳ degree of CINV rises.

关 键 词：乳腺癌 中医体质 化疗性恶心呕吐(CINV) 体质倾向 发生率 

分 类 号：R737.9[医药卫生—肿瘤]