补阳还五汤联合手指健智操治疗阿尔茨海默病疗效观察  

Observation of Buyang Huanwu Tang Combined with Finger Exercise for Alzheimer Disease

作　　者：张丽 黄伟钢 祁风[2] 

机构地区：[1]广州市荔湾区金花街社区卫生服务中心,广东广州510140 [2]广州医科大学附属第三医院荔湾医院,广东广州510170

出　　处：《新中医》2017年第8期148-151,共4页New Chinese Medicine

基　　金：广州市荔湾区科技和信息化局科研项目(2016080047);广东省中医药局科研项目(20171210)

摘　　要：目的:观察补阳还五汤联合手指健智操治疗阿尔茨海默病的临床疗效。方法:选取200例阿尔茨海默病患者为研究对象,随机分为补阳还五汤组、手指健智操组、联合组以及对照组各50例。对照组给予常规治疗,补阳还五汤组在常规治疗基础上加服补阳还五汤,手指健智操组在常规治疗基础上加手指健智操,联合组同时实施上述3组的治疗方法。于治疗前及治疗12周后分别统计患者的长谷川痴呆量表(HDS)、阿尔茨海默病评定量表-认知量表(ADAS-cog)及日常生活能力量表(ADL)评分,观察4组不良反应发生情况。结果:治疗后,4组HDS评分均较治疗前升高(P<0.05);联合组、补阳还五汤组和手指健智操组的HDS评分均高于对照组(P<0.05);联合组的HDS评分均高于补阳还五汤组和手指健智操组(P<0.05)。治疗后,4组ADAScog评分及ADL评分均较治疗前降低(P<0.05);联合组、补阳还五汤组和手指健智操组的ADAS-cog评分及ADL评分均低于对照组(P<0.05);联合组的ADAS-cog评分及ADL评分均低于补阳还五汤组和手指健智操组(P<0.05)。治疗过程中,对照组出现2例恶心呕吐;补阳还五汤组出现1例腹泻;联合组和手指健智操组均未出现明显不良反应。结论:补阳还五汤联合手指健智操治疗可有效改善阿尔茨海默病患者的认知功能,提高日常生活能力。Objective. To observe the clinical effect of Buyang Huanwu tang combined with finger exercise for Alzheimer disease. Methods Selected 200 cases of patients with Alzheimer disease as study objects, and divided them into Buyang Huanwu tang group, finger exercise group, combination group, and the control group randomly, 50 cases in each group. The four groups all received routine treatment. In addition, Buyang Huanwu tang group received Buyang Huanwu tang, finger exercise group received finger exercise, and combination group received Buyang Huanwu tang combined with finger exercise. Before and after twelve weeks of treatment, respectively recorded scores of Hasegawa dementia scale （HDS）, Alzheimer disease assessment scale-cognitive section （ADAS-cog） and activity of daily living （ADL） scale in all groups, and observed adverse reaction in four groups. Results： After treatment, HDS scores in four groups were increased when compared with those before treatment （P 〈0.05）. HDS scores in combination group, Buyang Huanwu tang group and finger exercise group were all higher than those in the control group （P 〈 0.05）, and HDS scores in combination group were higher than those in Buyang Huanwu tang group and finger exercise group （P〈 0.05）. After treatment, scores of ADAS-cog and ADL in four groups were decreased when compared with those before treatment （P 〈 0.05）. Scores of ADAS-cog and ADL in combination group, Buyang Huanwu tang group and finger exercise group were all lower than those in the control group （P 〈 0.05）, and scores of ADAS-cog and ADL in combination group were lower than those in Buyang Huanwu tang group and finger exercise group （P〈 0.05）. During treatment, two cases of nausea and vomiting were found in the control group; one case of diarrhea was found in Buyang Huanwu tang group; no obvious adverse reaction was found in combination group and finger exercise group. Conclusion：The therapy of Buyang Huanwu tang combined with finger exercise can effectively i

关 键 词：阿尔茨海默病 气虚血瘀证 补阳还五汤 手指健智操 长谷川痴呆量表(HDS) 阿尔茨海默病评定量表-认知量表(ADAS-cog) 日常生活能力量表(ADL) 

分 类 号：R749.1[医药卫生—神经病学与精神病学]