阿托品与近视控制  

Atropine in the control of myopia

作　　者：张悦[1] 陈伟[1] 梁旭[1] 

机构地区：[1]天津市眼科医院玻璃体视网膜二科,天津300020

出　　处：《中国城乡企业卫生》2017年第8期46-48,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

基　　金：国家自然科学基金项目(B1500705)

摘　　要：随着高度近视及其伴随的健康风险逐渐增加,在儿童时期控制近视的发展越来越重要。控制近视的治疗方法包括使用框架眼镜、隐形眼镜和药物,后者似乎是最有希望的。在本文中我们回顾了既往关于儿童近视发展过程中局部使用阿托品眼药水的疗效,并讨论不同浓度(1.0%、0.5%、0.1%和0.01%)阿托品的疗效及安全性。局部使用阿托品能减少近视进展和降低眼轴的增加并呈现剂量相关性,但回弹现象更容易发生在高浓度组。阿托品的使用已被证明具有安全性,但高浓度可以引起瞳孔散大、调节降低和视近,0.01%的阿托品有最好的治疗预期,在对近视的控制上同高浓度组是一样有效的,而在临床应用中发现无明显瞳孔扩张性,同时对视力和调节力影响不大,现已逐渐成为控制近视发展的一个有力选择。With increased high myopia and its attendant health risks, the development of myopia control is becoming more and more important in childhood. Treatments for children with reduced myopia include glasses, contact lenses and medication, of which the latter appears to be the most promising. In this article, we review the efficacy of the local application of atropine eye drops in the process of children＇s myopia development, and discuss the efficacy and safety profiles when atropine is used at different concentrations （1.0%, 0.5%, 0.1% and 0.01%）. Local atropine reduces the progression of myopia and the increase in ocular axial in children with a dose-related manner, but the rebound is more likely to occur in a higher dose group. Atropine has been shown to be safe, but high concentrations can cause dilation of the pupils, loss of accommodation and near vision. 0.01% atropine has the best treatment, with clinically insignificant amounts of pupil dilation, near vision, and accommodation loss but remains as effective as the high concentration group in the control of myopia. It has become a powerful choice for controlling myopia.

关 键 词：阿托品 近视 控制 预防 

分 类 号：R778.11[医药卫生—眼科]