希德联合赛乐特治疗伴有焦虑障碍的抑郁症的临床观察  

To Study the Clinical Efficacy of the Treatment of Depression with Anxiety Disorders by Both Tandospirone Citrate and Paroxetine

作　　者：胡庆菊 梁炜明 谭秀梅 邓秀如 李素娟 

机构地区：[1]东莞市第三人民医院临床心理科,广东东莞523326 [2]锦州医科大学附属第一医院,辽宁锦州121000

出　　处：《锦州医科大学学报》2017年第4期83-85,共3页Journal of Jinzhou Medical University

摘　　要：目的探究枸橼酸坦度螺酮片(希德)联合盐酸帕罗西汀(赛乐特)治疗伴有焦虑障碍的抑郁症的疗效和安全性。方法将89例被诊断为伴有焦虑障碍的抑郁症患者随机分为两组,研究组(希德加赛乐特组)48例,对照组(赛乐特组)41例,分别给予希德联合赛乐特及单纯赛乐特治疗4 w,于治疗前、第1、2、4周采用汉密顿焦虑量表(HAMA)和抑郁量表(HAMD)及不良反应量表(TESS)评定疗效及安全性,同时采用国内四级评定标准进行临床评估。结果 1、2 w末研究组明显好于对照组的疗效。1 w末研究组的有效率是83.3%,对照组的有效率是51.2%,4 w末研究组的有效率是91.7%,对照组的有效率是82.9%。两组汉密顿焦虑量表(HAMA)和抑郁量表(HAMD)的总分结果于1、2 w末有显著性差异。不良反应量表(TESS)两组无显著性差异。结论希德联合赛乐特治疗伴有焦虑障碍的抑郁症具有增加疗效,见效加快,不增加不良反应的作用。Objective To explore the clinical efficacy and security of the treatment of anxiety depression in both Tandospironecitrate （Sid） and Paroxetine. Methods 81 cases with anxiety disorders were randomly selected in our hospital and divided into twogroups, the test group and the control group. Both Sid and Paroxetine were used in test group （48 patients） to treat anxiety depressionwhile Paroxetine was used in control group. The cases were treated for 4 weeks. Some medical scales were used to evaluate the efficacyand safety before and after these patients were treated for l week, 2 weeks and 4 weeks, including Hamilton anxiety scale （HAMA）,Hamilton depression scale （HAMD） and adverse reactions of scale （TESS）. The national level four evaluation criteria were also usedfor clinical evaluation. Results After 1 - 2 weeks＇ treatment, the clinical efficacy of the test group was significantly better than thatof the control group. After one week, the effective rate of test group was 83.3 % , and that of control group was 51.2%. 4 weeks lat-er, the test group was 91.7%, and the control group was 82. 9%. The two group＇s results of the HAMA and HAMD were significantlydifferent after 1 and 2 weeks. And there was no significant difference between the two groups of TESS. Conclusion Combined use ofSid and Paroxetine can quickly and effectively treat the anxiety depression with no increase in adverse reactions.

关 键 词：焦虑障碍 抑郁症 希德 赛乐特 量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]