急性脑梗死患者颈动脉硬化与血清LTB4、MMP-9表达水平的相关性研究  

Study on the relationship between carotid atherosclerosis and serum LTB4,MMP-9 levels in patients with acute cerebral infarction

作　　者：马红岗[1] 朱斐斐[2] 王亚仙[1] 

机构地区：[1]浙江省湖州市中心医院神经内科,浙江湖州313000 [2]浙江省湖州市中心医院药剂科,浙江湖州313000

出　　处：《中国医药导报》2017年第23期52-55,共4页China Medical Herald

基　　金：浙江省湖州市科学技术局项目(2014GYB36)

摘　　要：目的探讨急性脑梗死患者颈动脉硬化与血清白三烯B4(LTB4)、基质金属蛋白酶-9(MMP-9)表达水平的相关性。方法选取2014年1月~2016年1月于湖州市中心医院神经内科接受治疗的200例确诊急性脑梗死患者,根据是否存在颈动脉硬化分为颈动脉硬化组(143例)和对照组(57例);再根据内膜增厚程度,将颈动脉硬化组分为内膜增厚组(22例)、斑块组(67例)和颈动脉狭窄组(54例)。比较各组间血清LTB4、MMP-9浓度的差异。结果血清LTB4、MMP-9在颈动脉硬化组中的表达水平明显高于对照组,差异有统计学意义(P<0.05)。在颈动脉狭窄组中血清LTB4、MMP-9的表达高于颈动脉斑块组及内膜增厚组,差异有统计学意义(P<0.05);颈动脉斑块组LTB4、MMP-9表达水平高于内膜增厚组,差异有统计学意义(P<0.05);且Spearman相关检验提示血清LTB4、MMP-9表达水平与颈动脉硬化严重程度呈正相关(P<0.05)。结论急性脑梗死患者中颈动脉硬化及其程度与血清LTB4、MMP-9表达水平有关。Objective To study the relationship between serum levels of leukotriene B4 （LTB4）, matrix metallopeptidase 9 （MMP-9） and the degree of arteriosclerosis in the patients with acute cerebral infarction. Methods From January 2014 to January 2016, 200 patients with acute cerebral infarction were selected. They were divided into carotid atherosclerosis group （143 cases） and control group （57 cases）, according to whether there exist carotid atherosclerosis. Then, the patients in the carotid atheroselerosis group were divided into intima thickening group （22 cases）, plaque group （67 cases） and carotid artery stenosis group （54 cades）, according to the degree of intimal thickening. The levels of serum LTB4, MMP-9 in the groups were compared. Results The levels of serum LTB4, MMP-9 in the carotid atherosclerosis group were obviously higher than those in the control group, with statistically significant difference （/9 〈 0.05）. The ex- pression in the carotid artery stenosis group was significantly higher than that in the carotid plaque group and intima thickening group, and Spearman correlation test showed the levels of LTB4 and the MMP-9 were positively related to severity of carotid atherosclerosis （P 〈 0.05）. Conclusion The levels of serum LTB4 and MMP-9 are positively corre- lated with the carotid atherosclerosis and the degree in patients with acute cerebral infarction.

关 键 词：血清白三烯B4 基质金属蛋白酶-9 颈动脉硬化 

分 类 号：R74[医药卫生—神经病学与精神病学]