食道鳞癌术后复发的临床病理特征与预后  

The clinical and pathologic characteristics and prognosis of postoperative recurrence esophageal squamous cell carcinoma

作　　者：杨颖[1] 刘传玲[1] 贾军[1] 孙志伟[1] 肖艳洁 余靖[1] 杜丰[1] 张晓东[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所,北京100142

出　　处：《中国地方病防治》2017年第4期438-439,共2页Chinese Journal of Control of Endemic Diseases

基　　金：国家自然科学基金项目;(项目编号:8160294)

摘　　要：目的研究食道鳞癌术后复发患者的临床及病理特征与总生存的关系。方法采用回顾性队列研究的方法,搜集53例食道鳞癌根治术后复发患者的15项临床及病理因素,应用Cox回归模型行生存分析,确定预后相关风险指标,构建预后评分。结果年龄>55岁、肿瘤长径>3 cm、淋巴结转移阳性、未行术后化疗、无病生存期<6个月以及复发时白蛋白<45 g/L为术后复发患者的预后不良指标,具备0-1个指标为低危组,2-3个为中危组,4个及以上为高危组,各个组别的总生存期差别有统计学意义(P<0.0001)。结论食道鳞癌根治术后复发患者的临床及病理特征可预测预后,指导患者的治疗随访。Objective To estimate the association between clinical and pathologic features and prognosis among recurrent esophageal squamous cell carcinoma patients with radical surgery; and construct a prognosis score. Methods It was a retrospective cohort study. Fifteen clinical and pathologic features of fifty-three recurrent patients were collected and analyzed by Cox regression. Prognosis related risk factors were determined and selected to build a prognosis score that predicted patients＇ overall survival.Results 55 years of age,tumor size3cm,and pathologically confirmed lymph node metastasis; and lack of post-operation chemotherapy,disease free survival6 months and albumin 45g/L at relapse were related to poor prognosis. Prognosis was categorized into three groups： poor with 0-1 risk factors; median with 2-3 risk factors and good with 4-6 risk factors. The differences between risk groups were statistically significant（ P〈0.0001）. Conclusion Selected clinical and pathologic characteristics could predict prognosis among esophageal squamous cell carcinoma patients with recurrence,which was important in patients ＇treatment and follow-up.

关 键 词：食道鳞癌 术后复发 临床特性及病理特征 预后 

分 类 号：R571[医药卫生—消化系统]