表观遗传DNA甲基化和组蛋白修饰与疾病关系的研究进展  

Advances in the Relationship between Epigenetic DNA Methylation and Histone Modification with Diseases

作　　者：晏强[1] 周献青 薛雯[1] 戴勇 

机构地区：[1]解放军第一八一医院肾脏科全军器官移植与透析治疗中心广西代谢性疾病研究重点实验室,广西桂林541002 [2]广西师范大学生命科学学院,广西桂林541004 [3]暨南大学第二临床医学院深圳市人民医院临床医学研究中心,广东深圳518020

出　　处：《医学综述》2017年第16期3160-3163,3169,共5页Medical Recapitulate

摘　　要：近年来,表观遗传修饰在许多重大疾病中的致病机制和临床应用的研究受到广泛关注。在表观遗传修饰中,DNA甲基化和组蛋白修饰调节剂作为疾病发生、发展和临床诊断治疗的生物标志物,而DNA甲基化水平的高低和组蛋白修饰位点的不同均可能对疾病产生影响,DNA甲基化导致抑癌基因转录失活,组蛋白的异常修饰与肿瘤发生、发展相关。因此,探讨DNA甲基化和组蛋白修饰与疾病的关系,在疾病治疗过程中寻找靶向标志物,更深入地研究疾病的致病机制,可为疾病的预防、诊断和治疗提供新途径。In recent years, epigenetic modification has been widely concerned in the pathogenesis and clinical application of many major diseases. In the epigenetic modification, DNA methylation modulators and histone modulators are used as biomarkers for the development and clinical diagnosis of diseases, the different levels of DNA methylation and histone modification sites may affect the occurrence and development of the disease process. DNA methylation leads to inactivation of tumor suppressor genes, and histone abnormalities are associated with tumor development. Therefore, the study of DNA methylation and histone modification and disease, to find the targeted markers during treatment, a deeper study of the pathogenesis of the disease may provide a new way for the prevention, diagnosis and treatment.

关 键 词：表观遗传 DNA甲基化 组蛋白修饰 

分 类 号：R394.3[医药卫生—医学遗传学]