葡萄膜炎伴发白内障术中应用小剂量曲安奈德的效果  

The efficacy of small doses of triamcinolone acetonide in the surgery for concomitant cataract with anterior uveitis

作　　者：连黎红[1] 马成霞[1] 谭凤玲[1] 陈佳佳[1] 

机构地区：[1]郑州大学第一附属医院眼科河南省眼科医院,郑州450052

出　　处：《中华眼外伤职业眼病杂志》2017年第8期623-626,共4页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的评价前葡萄膜炎伴发白内障手术前房注射小剂量曲安奈德控制术后炎症的有效性及安全性。方法前葡萄膜炎伴发白内障35例（42眼）随机分成2组，临床试验组和对照组各21眼。所有患者均进行透明角膜切口晶状体超声乳化联合人工晶状体植入术，手术结束前试验组前房内注射曲安奈德2mg／0．05ml，对照组注射等量灌注液。比较两组术后不同时间点视力、眼压、前房炎症反应及角膜内皮细胞密度。结果术后1、3、7d，试验组前房炎症反应均较对照组轻，差异有统计学意义（P=0．043，0．046，0．010），术后30d两组前房炎症反应差异无明显统计学意义（P=0．311），两组视力、眼压、角膜内皮细胞密度差异均无统计学意义（均P〉0．05）。结论前葡萄膜炎伴发白内障手术中前房注射小剂量曲安奈德可减轻术后前房炎症反应，是一种安全有效方法。Objective To evaluate the efficacy and safety of small doses of triamcinolone acetonide （TA） anterior chamber injection in anterior uveitis concomitant cataract surgery. Methods Forty-two eyes of 35 patients with anterior uveitis concomitant cataract were performed phacoemulsification and intraocular lens implantation. All patients were randomly divided into two groups： TA group, 21 eyes received anterior chamber injections of TA 2rag/0.05ml before the operation finished; control group,21 eyes received anterior chamber injection of equivalent perfusate. The best corrected visual acuity （BCVA）, intraocular pressure, anterior chamber reaction and corneal endothelial cell density in two groups were observed and compared at different time points after operation. Results The anterior chamber reaction at 1,3 and 7 days after operation in TA group was lower than that in control group, the differences were statistically significant （P = 0. 043,0. 046, 0. 010 ）. The difference in anterior chamber reaction 30 days after operation was not statistically significant （P = 0.311 ）. The difference in BCVA, intraocular pressure and corneal endothelial cell density 30 days after surgery between the two groups were not statistically significant （ all P 〉 0.05 ）. Conclusion Anterior chamber injection of small does of TA in anterior uveitis concomitant cataract surgery can reduce the postoperative anterior chamber reaction and it is a safe and effective method.

关 键 词：葡萄膜炎 前部 白内障 并发性 曲安奈德 前房注射 

分 类 号：R779.6[医药卫生—眼科]