以牙龈病变为首发症状的非霍奇金淋巴瘤  

Gingival Lesions Presenting as the First Symptom:Clinicopathologic Characteristics of Gingival non-Hodgkin's Lymphoma

作　　者：孙维克[1] 巩雪梅[1] 董大群[1] 周卉卉[2] 

机构地区：[1]滨州医学院口腔医学院,山东烟台264003 [2]青岛医学院附属烟台毓璜顶医院病理科,山东烟台264003

出　　处：《口腔医学研究》2017年第8期874-876,共3页Journal of Oral Science Research

基　　金：山东省医药卫生科技发展计划项目(编号:2013WS0039)

摘　　要：目的:探讨以牙龈病变为首发症状的淋巴瘤临床病理分析及预后转归情况。方法:回顾2011~2017年4例以牙龈病变为首发症状的非霍奇金淋巴瘤,结合国内外关于牙龈的淋巴瘤的相关文献报道,分析其临床特点及组织病理学类型,并随访其治疗情况及预后。结果:4例牙龈淋巴瘤患者男1例,女3例,平均年龄59岁。发生部位上颌牙龈3例,下颌牙龈1例。其中弥漫大B细胞淋巴瘤2例,均为生发中心起源,间变大细胞淋巴瘤1例及浆细胞瘤1例。结论:牙龈淋巴瘤非常罕见,几乎均为非霍奇金淋巴瘤,以弥漫大B细胞淋巴瘤为主,牙龈淋巴瘤的确诊依赖病理活检,免疫标记对明确诊断、分型及鉴别诊断具有一定的诊断价值。Objective：To investigate the clinicopathologic characteristics and prognosis of gingival non-Hodgkin＇s lympahoma（NHL）.Methods：Four cases of NHL whose first symptoms were gingival lesions were analyzed.The clinicopathologic and immunohistochemical characteristics were retrospectively studied and the relevant literatures were reviewed.Results：The median age of 4patients was 59（43-69）.They were 1male and 3females.Three cases occurred in maxillary gingival and one case occurred in mandibular gingival.Two cases were diffused large B cell lymphoma（DLBCL）,1case was anaplastic large cell lymphoma,ALK-negative（ALCL,ALK-negative）,and the last one was plasma cell neoplasms.Conclusion：Lymphoma of gingival is very rare and almost NHL,predominated by DLBCL.The diagnosis of gingival lymphoma depends on pathological biopsy.Immunohistochemistry is conducive to diagnosis,typing,and differential diagnosis.

关 键 词：牙龈 淋巴瘤 临床病理 免疫组化 

分 类 号：R733.1[医药卫生—肿瘤]