玻璃体替代物的研究进展  

Research progress of vitreous substitutes

作　　者：张鹏程[1] 严宏[1,2] 郭辰峻 

机构地区：[1]第四军医大学唐都医院眼科,陕西西安710038 [2]重庆医科大学附属第一医院眼科学重庆市市级重点实验室重庆市眼科研究所,重庆400016

出　　处：《转化医学电子杂志》2017年第8期67-71,共5页E-Journal of Translational Medicine

基　　金：国家自然科学基金(30872837)

摘　　要：由于玻璃体不可再生,当出现视网膜疾病如复杂视网膜脱离、黄斑裂孔、糖尿病视网膜病变并发症及眼外伤需要行玻璃体视网膜手术治疗时必须有玻璃体替代物填充才能有效顶压视网膜、重建视功能.目前的玻璃体替代物由于固有的问题仅能短期填充或术中应用,故寻求理想的玻璃体替代物仍是眼科学界的研究热点.本文就玻璃体替代物,尤其是智能水凝胶、可折叠囊袋式人工玻璃体等新型产品的研究进展作简要综述.Vitreous body is not renewable. That is inevitable on vitreoretinal diseases,such as complicated retinal detachment,macular holes,complications of diabetic retinopathy,and ocular trauma. At this point,vitreous substitutes are needed for providing effective intraocular pressure for reattachment of retina and reconstruction of the visual function during vitreo-retinal surgery.Current available options,due to inherent problems,can only be used for short-term tamponade or temporary intraoperative application. And also because of non-renewable of vitreous body,the research for ideal vitreous substitutes still is a hot topic in ophthalmic field. Here we review the research progress of vitreous substitutes,especially new options such as smart hydrogels,foldable capsular vitreous body.

关 键 词：玻璃体替代物 水凝胶 折叠式人工玻璃体 视网膜疾病 

分 类 号：R776.4[医药卫生—眼科] R774.1[医药卫生—临床医学]