卷柏属药用植物的抗氧化作用及品质评价  

Antioxidant Effect of Selaginella Medicinal Plants and Its Quality Review

作　　者：赵平[1] 徐健[1] 李娟[1] 

机构地区：[1]教育部中药资源与中药复方重点实验室湖北中医药大学药学院,武汉430065

出　　处：《医药导报》2017年第9期1010-1015,共6页Herald of Medicine

基　　金：国家自然科学基金资助项目(30470193);湖北中医药大学校级课题(XJ2014KJ008)

摘　　要：该文对卷柏属药用植物抗氧化作用及其物质基础的研究进行介绍和评述。在对卷柏属多种药用植物进行系统比较鉴定研究的基础上,发现其乙酸乙酯部位(Et Ac)及黄酮类化合物对黄嘌呤氧化酶(XOD)、脂质氧化酶(LOX)或(和)环氧化酶-2(COX-2)均具有一定程度的抑制活性。从该属3种资源植物分离获得14种双黄酮、1种黄酮类化合物、5种黄酮苷化合物,其中新化合物5种,并首次从这些植物中发现了15种成分。穗花杉双黄酮(AME)、罗伯斯塔黄酮和罗伯斯塔黄酮-4'-甲醚双黄酮3种成分为卷柏属植物共同的抗氧化特征性成分,可作为其共同的活性成分指标用以评价其品质。数种卷柏属药用植物具有较强的抗柯萨奇病毒作用及抗肿瘤作用,这与它们能整体多靶点抑制多种氧化酶、减少自由基对组织的损伤密切相关。This paper aimed to introduce and review the antioxidant and material base of selaginella medicinal plants. On the basis of the systematic identification of Selaginella medicinal plants, we found that the ethyl acetate extract and flavonoids could inhibit the activity of XOD, LOX or/and COX-2 to some extent. Fourteen biflavonoids, one flavonoid and five flavonoid glycosides have been isolated from three resource plants, among them five compounds ＂were firstly reported and fifteen compounds ＂were firstly isolated in selaginella plants. Amentoflavone （AME）,robustaflavone and robustaflavone-4 ＇-dimethylether are three common characteristic constituents of Selaginella plants,which can act as marks of common active ingredients and be applied to evaluate the quality of selaginella. Further studies found that some plants had stronger anti-Coxsackie virus and anti-tumor effects,and their mechanisms were associated with inhibiting multiple oxidase and mitigating harm of free radicals due to whole function.

关 键 词：卷柏属植物 黄嘌呤氧化酶 脂质氧化酶 环氧化酶-2 双黄酮 抗氧化 

分 类 号：R282.71[医药卫生—中药学] R979.1[医药卫生—中医学]