China＇s flourishing synthetic organofluorine chemistry：innovations in the new millennium  

作　　者：Qinghe Liu Chuanfa Ni Jinbo Hu 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《National Science Review》2017年第3期303-325,共23页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(21632009,21472221,21421002 and21372246);the National Basic Research Program of China(2015CB931900);the Key Programs of the Chinese Academy of Sciences(KGZD-EW-T08);the Key Research Program of Frontier Sciences of CAS(QYZDJ-SSW-SLH049);the Shanghai Academic Research Leader Program(15XD1504400);the Shanghai Rising-Star Program(16QA1404600);the Youth Innovation Promotion Association CAS(2014231)

摘　　要：The new millennium has witnessed the rapid development of synthetic organofluorine chemistry all over the world, and chemists in China have made significant contributions in this field. This review aims to provide a brief introduction to China's primary innovations from 2000 to early 2017, covering fluorination,fluoroalkylation, fluoromethylthiolation, fluoroolefination and polyfluoroarylation, as well as synthesis with fluorinated building blocks. Recent advances in the chemistry of difluorocarbene and the chemistry of carbon–fluorine bond activation are also discussed. As a conclusion, the review ends with some personal perspectives on the future development of China's synthetic organofluorine chemistry.The new millennium has witnessed the rapid development of synthetic organofluorine chemistry all over the world, and chemists in China have made significant contributions in this field. This review aims to provide a brief introduction to China＇s primary innovations from 2000 to early 2017, covering fluorination,fluoroalkylation, fluoromethylthiolation, fluoroolefination and polyfluoroarylation, as well as synthesis with fluorinated building blocks. Recent advances in the chemistry of difluorocarbene and the chemistry of carbon–fluorine bond activation are also discussed. As a conclusion, the review ends with some personal perspectives on the future development of China＇s synthetic organofluorine chemistry.

关 键 词：FLUORINE organic chemistry synthetic methods FLUORINATION TRIFLUOROMETHYLATION trifluoromethylthiolation DIFLUOROMETHYLATION difluoroalkylation fluoromethylation fluoroolefination 

分 类 号：O622.2-1[理学—有机化学]