DIFLUOROMETHYLATION

作品数：20被引量：27H指数：3
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Nickel-catalyzed decarboxylative difluoromethylation and alkylation of alkenes
《Chinese Chemical Letters》2025年第3期253-258,共6页Zhenkang Ai Hui Chen Xuebin Liao 
financial support from the National Natural Science Foundation of China(NSFC,No.21877067);Tsinghua-Peking Centre for Life Science。
Herein,we describe a nickel-catalyzed reductive decarboxylative difluoromethylation reaction of alkenes using inexpensive and easy-to-handle difluoroacetic anhydride(DFAA)/pyridine N-oxide reagent system.A variety of ...
关键词：NICKEL DIFLUOROMETHYLATION Difluoroacetic anhydride Decarboxylative ALKENES 
Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods
《Chinese Journal of Chemistry》2025年第2期155-160,共6页Xuliang Han Haodong Liu Xiaomei Feng Fuchao Jia Zengdian Zhao Xinjin Li 
support by the National Natural Science Foundation of China(22101157)is gratefully acknowledged;We are very grateful to Prof.Xiao Shen(Wuhan University,China)for helpful discussion.
The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri- and difluoromethylation of isocyanides and N-arylacr...
关键词：TRIFLUOROMETHYLATION DIFLUOROMETHYLATION Radical Single-electron transfer CATALYST-FREE Magnetic field Electromagnetic induction ISOCYANIDES 
Visible-light induced photocatalyst-free difluoromethylation of quinoxalinones with difluorosulfones
《Green Synthesis and Catalysis》2024年第4期277-281,共5页Linlin Shi Tiantian Li Wenjing Zhang Weinan Hu Xinju Zhu Yixin Lu Guang-Jian Mei 
Financial support from the National Natural Science Foundation of China(Nos.22101267,U1904212,U2004191 and 21803059)is gratefully appreciated.
Visible-light induced direct C–H difluoromethylation of quinoxalinones with 2-((difluoromethyl)sulfonyl)benzo[d]thiazole has been developed for the first time.A broad range of quinoxalinones were well tolerated and r...
关键词：Quinoxalinones DIFLUOROMETHYLATION Visible-light induced Photocatalyst-free Difluorosulfones 
Photoexcitation of Dihydroquinazolinone Anionic Compounds:Difluoroalkylarylation and Difluoroalkylamination of Alkenes被引量：1
《CCS Chemistry》2024年第10期2549-2559,共11页Jian-Xiong Yang Jia-Qing Hu Qi Wen Jie Xu Yan Zhang Heng Jiang 
the National Natural Science Foundation of China(grant nos.22101176 and 22137003).
The direct excitation of dihydroquinazolinone(DHQ)anions by visible light has been demonstrated by photophysical experiments.The excited-state DHQ anion serves as both a potent reductant and a radical precursor in a r...
关键词：excited state anion difluoromethyl radical DIFLUOROMETHYLATION PHOTOCHEMISTRY radical chemistry 
General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis
《Science China Chemistry》2024年第8期2637-2646,共10页Meng He Yankai Yang Heng Zhang Zhipeng Guan Zhi-Bing Dong Hong Yi Aiwen Lei 
supported by the China Postdoctoral Science Foundation (2021M702516);the National Key R&D Program of China (2021YFA1500104);the National Natural Science Foundation of China (22031008);the Science Foundation of Wuhan(2020010601012192)。
CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their...
关键词：RADICAL DIFLUOROMETHYLATION alkenes/dienes/heteroaromatics difluoroacetic anhydride PHOTOREDOX 
Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions
《CCS Chemistry》2024年第1期165-176,共12页Huanhuan Song Weihao Li Xiaoying Wang Kaiteng Wang Jingwen Li Shuai Liu Pin Gao Xin-Hua Duan Jinbo Hu Mingyou Hu 
supported by National Natural Science Foundation of China(grant no.21901196);the Natural Science Basic Research Plan in Shaanxi Province of China(grant nos.2020JQ-016 and 2021GXLH-Z-096);the Fundamental Research Funds for the Central Universities(grant no.xhj032021007-01);Xi’an Jiaotong University(grant no.71211920000001).
A general method for the synthesis of bench-stable bis(difluoromethyl)pentacoordinate phosphoranes has been developed.The reaction is rapid,operationally simple,and easily scalable.The pentacoordinate phosphoranes can...
关键词：pentacoordinate phosphorane difluoromethyl radical DIFLUOROCARBENE DIFLUOROMETHYLATION FLUOROALKYLATION 
Switching from 2-pyridination to difluoromethylation:ligand-enabled nickel-catalyzed reductive difluoromethylation of aryl iodides with difluoromethyl 2-pyridyl sulfone
《Science China Chemistry》2023年第10期2785-2790,共6页Wei Du Qinyu Luo Zhiqiang Wei Xiu Wang Chuanfa Ni Jinbo Hu 
supported by the National Key Research and Development Program of China(2021YFF0701700);the National Natural Science Foundation of China(22271299,22261132514);the Natural Science Foundation of Shandong Province(ZR2021LFG006);the State Key Laboratory of Fluorine-Containing Functional Membrane Materials。
The divergent reductive cross-coupling with an ambident electrophile is rare.Previously,we demonstrated a nickel-catalyzed reductive 2-pyridination of aryl iodides with difluoromethyl 2-pyridyl sulfone(2-Py SO_(2)CF_(...
关键词：nickel catalysis DIFLUOROMETHYLATION 2-PySO_(2)CF_(2)H reductive cross-coupling 
A bench-stable reagent for C-4 selective deuteriodifluoromethylation of azines
《Chinese Chemical Letters》2022年第11期4817-4821,共5页Junqing Liang Lefeng Dong Feng Qian Yijin Kong Mingxia Wang Xiaoyong Xu Xusheng Shao Zhong Li 
financial supported by Innovation Program of Shanghai Municipal Education Commission(No.201701070002E00037);supported by National Key Research Program of China(No.2017YFD0200505);the Fundamental Research Funds for the Central Universities。
Deuteriodifluoromethyl(CF_(2)D)is a challenging and important functional group due to difficult deuterium incorporation and lack of effective precursor reagents.Herein,we report a bench-stable reagent,deuteriodifluoro...
关键词：REAGENT DEUTERIUM DIFLUOROMETHYLATION C-4 selective AZINES 
Chemoselective desulfurization-fluorination/bromination of carbonofluoridothioates for the O-trifluoromethylation and O-bromodifluoromethylation of alcohols
《Science China Chemistry》2021年第8期1372-1379,共8页Jie Liu Haonan Xiang Lvqi Jiang Wenbin Yi 
This work was supported by the National Natural Science Foundation of China(21776138,22078161);the Fundamental Research Funds for the Central Universities(30920021124,30918011314);the Natural Science Foundation of Jiangsu(BK20180476);the Postdoctoral Science Foundation Funded Project(2019M661848);the Priority Academic Program Development of Jiangsu Higher Education Institutions,and the Center for Advanced Materials and Technology in Nanjing University of Science and Technology.
Herein,a method for synthesizing various alkyl trifluoromethyl and alkyl bromodifluoromethyl ethers using carbonofluoridothioates(R-OC(=S)F)as precursors has been described.Carbonofluoridothioates were obtained upon t...
关键词：carbonofluoridothioates trifluoromethyl ethers bromodifluoromethyl ethers FLUORINATION alkyl 
Base-Promoted Formylation and N-Difluoromethylation of Azaindoles with Ethyl Bromodifluoroacetate as a Carbon Source
《Chinese Journal of Chemistry》2021年第6期1477-1482,共6页Yang Li Ning Sun Cai-Lin Zhang Meng Hao 
the financial support from the National Natural Science Foundation of China(No.21503161);the Key Research&Development Project in Shaanxi Province(No.2017ZDXM-GY-040);the Doctoral Scientific Research Foundation of Xi'an Polytechnic University(No.107020336).
We reported for the first time that ethyl bromodifluoroacetate directly reacts with azaindole without transition metal catalysis to produce a difluoromethyl protected 5-aldehyde group product in one step.It is worth m...
关键词：AZAINDOLES C1 building blocks DIFLUOROMETHYLENE Hydrolysis Synthetic methods 
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