DIFLUOROCARBENE

作品数：22被引量：16H指数：2
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Efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates:A concise synthesis of difluoromethylene-containing 1,4-thiazine derivatives
《Chinese Chemical Letters》2024年第4期367-370,共4页Zhiwei Chen Heyun Sheng Xue Li Menghan Chen Xin Li Qiuling Song 
Financial support from National Natural Science Foundation of China(Nos.21931013 and 22271105);Natural Science Foundation of Fujian Province(No.2022J02009);Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University;the Instrumental Analysis Center of Huaqiao University for analysis support;the Subsidized Project for Cultivating Postgraduates’Innovative Ability in Scientific Research of Huaqiao University。
A practical method for the construction of difluoromethylene-containing 1,4-thiazine moieties using readily available diethyl bromodifluoromethanephosphonate(BrCF_(2)PO(OEt)_(2))as difluorocarbene precusor has been de...
关键词：DIFLUOROMETHYLENE Pyridinium 1 4-zwitterionic thiolates 1 4-Thiazine derivatives 
Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities
《Science China Chemistry》2024年第3期953-962,共10页Yuan-Qing Gu Hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan Guo-Kai Liu 
supported by the National Natural Science Foundation of China(92056201);Guangdong Basic and Applied Basic Research Foundation(2023A1515011008);Shenzhen Science and Technology Program(the Stable Support Plan Program 20220808130958001)。
Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low reactivity.Herein,we report the design and synthesis of difluor...
关键词：difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation DIFLUOROCARBENE 
Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions
《CCS Chemistry》2024年第1期165-176,共12页Huanhuan Song Weihao Li Xiaoying Wang Kaiteng Wang Jingwen Li Shuai Liu Pin Gao Xin-Hua Duan Jinbo Hu Mingyou Hu 
supported by National Natural Science Foundation of China(grant no.21901196);the Natural Science Basic Research Plan in Shaanxi Province of China(grant nos.2020JQ-016 and 2021GXLH-Z-096);the Fundamental Research Funds for the Central Universities(grant no.xhj032021007-01);Xi’an Jiaotong University(grant no.71211920000001).
A general method for the synthesis of bench-stable bis(difluoromethyl)pentacoordinate phosphoranes has been developed.The reaction is rapid,operationally simple,and easily scalable.The pentacoordinate phosphoranes can...
关键词：pentacoordinate phosphorane difluoromethyl radical DIFLUOROCARBENE DIFLUOROMETHYLATION FLUOROALKYLATION 
Synthesis of 2-Trifluoromethyl-4-aminoquinolines via Heating-Promoted Multi-component Reaction of CF_(3)-Imidoyl Sulfoxonium Ylides and Amines with Difluorocarbene as a C1 Synthon
《Chinese Journal of Chemistry》2023年第23期3205-3210,共6页Guangming Wei Chen Li Haoyuan Wang Zhengkai Chen Xiao-Feng Wu 
financial support from K.C.Wong Education Foundation(GJTD-2020-08).
A thermally-induced multi-component reaction of CF_(3)-substituted imidoyl sulfoxonium ylides(TFISYs),amines and(triphenylphosphonio)difluoroacetate(PDFA)has been developed,allowing a facile access to 2-trifluoromethy...
关键词：CF_(3)-Imidoyl sulfoxonium ylides DIFLUOROCARBENE Multi-component reaction 2-Trifluoromethyl-4-aminoquinolines N-Heterocyclic compounds 
Oxidation of Difluorocarbene by Pyridine N-Oxide and Ensuing Access to Carbamoyl Fluorides被引量：1
《Chinese Journal of Chemistry》2023年第22期2981-2987,共7页Hai-Jun Tang Xue-Min Shi Xiao-Yu Zhu Cheng-Qiang Wang Chao Feng 
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(grant no.22271151)and the Distinguished Youth Foundation of Jiangsu Province.
A practical one-pot preparation of carbamoyl fluorides from easily obtained pyridine N-oxide,commercially available secondary amines and synthetically versatile difluorocarbene precursors(Ruppert-Prakash reagent or Ch...
关键词：Difluorocarbene Pyridine N-oxide Fluorophosgene Carbamoyl fluorides AMINES FLUORINE 
Mechanochemical Difluoromethylations of Alcohols被引量：1
《CCS Chemistry》2023年第8期1737-1744,共8页Pit van Bonn Jinbo Ke Christopher Weike Jas SWard Kari Rissanen Carsten Bolm 
research was made possible by the generous support of the Rhine-Westphalia Technical University of Aachen(RWTH Aachen University);We also acknowledge the Alexander von Humboldt Foundation for support of K.R.(AvH research award).
Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill.The protocol could be applied to primary,secondary,and tertiary alcohols,yielding the corresponding p...
关键词：MECHANOCHEMISTRY ball milling solventfree reaction DIFLUOROCARBENE difluoromethyl ether 
Single-atom skeletal editing of 2H-indazoles enabled by difluorocarbene被引量：1
《Science China Chemistry》2023年第7期1975-1981,共7页Yao Zhou Fuling Chen Ziru Li Junjie Dong Jingnan Li Bohao Zhang Qiuling Song 
supported by the National Natural Science Foundation of China(21931013,22271105);the Natural Science Foundation of Fujian Province(2022J02009);the Science and Technology Research Project of Education Department of Hubei Province(B2021133);the Hubei Key Laboratory of Pollutant Analysis&Reuse Technology(PA190109)
A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated herein.Ethyl bromodifluoroacetate was severed as the difluorocarbene source in the current protocol,facilitating the cleava...
关键词：INDAZOLES skeletal editing DIFLUOROCARBENE N-N bond cleavage quinazolin-4(3H)-ones 
Difluorocarbene-derived rapid late-stage trifluoromethylation of 5-iodotriazoles for the synthesis of^(18)F-labeled radiotracers
《Chinese Chemical Letters》2023年第6期336-340,共5页Fang Yuan Hongbao Sun Cheng Yang Haojie Yang Lili Pan Xiaoyang Zhang Rong Tian Lingjun Li Wei Chen Xiaoai Wu Haoxing Wu 
financially supported by the National Natural Science Foundation of China(Nos.21977075,22271200,21801178,21907070,81971653);1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,Central Plains Science and Technology Innovation Leader Project(No.214200510008 to L.Li);Scientific and Technological Innovation Team of Colleges and Universities in Henan Province(No.21IRTSTHN001)。
Difluorocarbene has emerged as a valuable intermediate to synthesize fluorides.However,difluorocarbene-derived synthesis of^(19)F/^(18)F-trifluoromethyl triazoles has not been explored.Herein,we reported the Cu(I)-pro...
关键词：DIFLUOROCARBENE TRIFLUOROMETHYLATION TRIAZOLE Late-stage functionalization ^(18)F-Labeled radiotracer 
Deconstrutive Difunctionalizations of Cyclic Ethers Enabled by Difluorocarbene to Access Difluoromethyl Ethers被引量：1
《CCS Chemistry》2022年第12期3820-3831,共12页Heyun Sheng Jianke Su Xue Li Qiuling Song 
Financial support by the National Natural Science Foundation of China(grant no.21931013)and the Open Research Fund of the School of Chemistry and Chemical Engineering,Henan Normal University is gratefully acknowledged.The authors also thank the Instrumental Analysis Center of Huaqiao University for analysis support.
An unprecedented difluorocarbene-mediated C-O bond cleavage of cyclic ethers for the construction of difluoromethyl ethers is herein disclosed.This protocol is distinguished by its mild conditions,high efficiency,and ...
关键词：DIFLUOROCARBENE C-O bond cleavage cyclic ethers difluoromethyl ethers 
Atom Recombination of Difluorocarbene Enables 3-Fluorinated Oxindoles from 2-Aminoarylketones
《CCS Chemistry》2022年第5期1671-1679,共9页Guan Zhang Qianqian Shi Mengyuan Hou Kai Yang Shihui Wang Shuai Wang Wangyang Li Chaokun Li Jian Qiu Hetao Xu Lu Zhou Cece Wang Shi-Jun Li Yu Lan Qiuling Song 
Financial support from the National Natural Science Foundation of China(nos.21772046,2193103,and 22001038)are gratefully acknowledged.
Contrary to the traditional implementation as a difluoromethyl group and recently disclosed role of C1 synthons in synthetic organic chemistry,difluorocarbene(:CF_(2))is reported herein to proceed in unprecedented ato...
关键词：DIFLUOROCARBENE FLUORINATION REARRANGEMENT HETEROCYCLES reaction mechanism 
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