Deconstrutive Difunctionalizations of Cyclic Ethers Enabled by Difluorocarbene to Access Difluoromethyl Ethers  被引量:1

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作  者:Heyun Sheng Jianke Su Xue Li Qiuling Song 

机构地区:[1]Institute of Next Generation Matter Transformation,College of Materials Science and Engineering,Huaqiao University,Xiamen,Fujian 361021 [2]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007

出  处:《CCS Chemistry》2022年第12期3820-3831,共12页中国化学会会刊(英文)

基  金:Financial support by the National Natural Science Foundation of China(grant no.21931013)and the Open Research Fund of the School of Chemistry and Chemical Engineering,Henan Normal University is gratefully acknowledged.The authors also thank the Instrumental Analysis Center of Huaqiao University for analysis support.

摘  要:An unprecedented difluorocarbene-mediated C-O bond cleavage of cyclic ethers for the construction of difluoromethyl ethers is herein disclosed.This protocol is distinguished by its mild conditions,high efficiency,and wide substrate scope,which can tolerate both sensitive functional groups such as the hydroxyl group,olefin and C-C triple bonds,as well as complex molecules.It thus demonstrates excellent chemoselectivities and great potential for late-stage modification of pharmaceutical compounds and natural products.It is worth noting that this method not only introduces fluorine atoms into the final molecules,but it can also effectively form an ester or ether linkage.

关 键 词:DIFLUOROCARBENE C-O bond cleavage cyclic ethers difluoromethyl ethers 

分 类 号:O62[理学—有机化学]

 

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