Mechanochemical Difluoromethylations of Alcohols  

作　　者：Pit van Bonn Jinbo Ke Christopher Weike Jas SWard Kari Rissanen Carsten Bolm 

机构地区：[1]Institute of Organic Chemistry,RWTH Aachen University,52074 Aachen [2]Department of Chemistry,University of Jyvaskyla,40014 Jyväskylä

出　　处：《CCS Chemistry》2023年第8期1737-1744,共8页中国化学会会刊（英文）

基　　金：research was made possible by the generous support of the Rhine-Westphalia Technical University of Aachen(RWTH Aachen University);We also acknowledge the Alexander von Humboldt Foundation for support of K.R.(AvH research award).

摘　　要：Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill.The protocol could be applied to primary,secondary,and tertiary alcohols,yielding the corresponding products in excellent yields(up to 99%)after 1 h reaction time at room temperature.The transformations proceeded under solvent-free reaction conditions,followed by product purification by filtration,which drastically reduced the amount of waste generated during the process.

关 键 词：MECHANOCHEMISTRY ball milling solventfree reaction DIFLUOROCARBENE difluoromethyl ether 

分 类 号：O62[理学—有机化学]