General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis  

作　　者：Meng He Yankai Yang Heng Zhang Zhipeng Guan Zhi-Bing Dong Hong Yi Aiwen Lei 

机构地区：[1]School of Chemistry and Environmental Engineering,Wuhan Institute of Technology,Wuhan 430205,China [2]College of Chemistry and Molecular Sciences and Institute for Advanced Studies(IAS),Wuhan University,Wuhan 430072,China

出　　处：《Science China Chemistry》2024年第8期2637-2646,共10页中国科学（化学英文版）

基　　金：supported by the China Postdoctoral Science Foundation (2021M702516);the National Key R&D Program of China (2021YFA1500104);the National Natural Science Foundation of China (22031008);the Science Foundation of Wuhan(2020010601012192)。

摘　　要：CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their reactivity and preparation. Herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF_(2)H reagent. This scalable protocol enables the convenient synthesis of a range of CF_(2)H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

关 键 词：RADICAL DIFLUOROMETHYLATION alkenes/dienes/heteroaromatics difluoroacetic anhydride PHOTOREDOX 

分 类 号：O643.36[理学—物理化学] O644.1[理学—化学]