Nickel-catalyzed decarboxylative difluoromethylation and alkylation of alkenes  

作　　者：Zhenkang Ai Hui Chen Xuebin Liao 

机构地区：[1]State Key Laboratory of Molecular Oncology,School of Pharmaceutical Sciences,Peking-Tsinghua Center for Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Chinese Chemical Letters》2025年第3期253-258,共6页中国化学快报(英文版)

基　　金：financial support from the National Natural Science Foundation of China(NSFC,No.21877067);Tsinghua-Peking Centre for Life Science。

摘　　要：Herein,we describe a nickel-catalyzed reductive decarboxylative difluoromethylation reaction of alkenes using inexpensive and easy-to-handle difluoroacetic anhydride(DFAA)/pyridine N-oxide reagent system.A variety of C(sp^(3))-CF_(2)H containing compounds were prepared through a hydrodifluoromethylation process.Besides,various gem–difluoroalkenes bearing CF_(2)H group were synthesized via defluorinative reductive cross-coupling process from trifluoromethyl-substituted alkenes using this new reaction system.Difluoroacetic anhydride has been then extended to other common alkyl anhydrides,and the corresponding hydroalkylation and defluoroalkylation processes have been successfully achieved.This method features broad substrate scope,good functional group tolerance as well as high efficiency.

关 键 词：NICKEL DIFLUOROMETHYLATION Difluoroacetic anhydride Decarboxylative ALKENES 

分 类 号：O621.3[理学—有机化学]