bFGF调控DPSCs迁移、增殖和分化的研究进展  

Research progress on the regulatory effect of bFGF on dental pulp stem cell proliferation,migration and differentiation

作　　者：刘亚楠[1] 李祥伟[1] 孙宏晨[1] LIU Ya＇nan LI Xiangwei SUN Hongchen.(Department of Endodontics, Stomatology School of Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学口腔医院牙体牙髓科

出　　处：《口腔医学》2017年第8期746-750,共5页Stomatology

基　　金：吉林省科技发展计划项目(20140204018SF)

摘　　要：碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF or FGF-2)是一种强丝裂原,可促进中胚层和神经外胚层来源细胞有丝分裂,进而促进组织修复和再生。牙髓干细胞(Dental pulp stem cells,DPSCs)具有高度增殖、自我更新和多向分化潜能,被认为是牙组织工程的理想种子细胞之一,在牙髓组织修复和再生方面具有广阔应用前景。近来研究发现b FGF调控DPSCs迁移、增殖和分化。本文对其研究进展进行综述。Basic fibroblast growth factor （bFGF） is a kind of strong mitogen and can promote cell mitosis which derived from the mesoderm and neural ectoderm, thus promoting the repair and regeneration of tissues. Dental pulp stem cells （DPSCs） with the poten- tial of high proliferation, self-renewal and multi-directional differentiation are thought to be one kind of the ideal seed cells in the tooth tissue engineering and have a promising application prospect in dental pulp tissue repair and regeneration. Recent studies have found that bFGF has an important role in migration, proliferation and differentiation of DPSCs. This article reviews its research progress.

关 键 词：碱性成纤维细胞因子 牙髓干细胞 增殖 迁移 分化 

分 类 号：R780.2[医药卫生—口腔医学]