DHA-丝裂霉素C偶联前药的制备及角膜透过性研究  

Preparation of DHA-mitomycin C prodrug and its permeability on corneal

作　　者：陈卓[1] 石蕊[2] 谭李玉 张宇佳[1] 

机构地区：[1]西安医学院药学院,西安710021 [2]陕西省人民医院,西安710068

出　　处：《中国油脂》2017年第8期108-110,115,共4页China Oils and Fats

基　　金：陕西省教育厅专项科研计划项目(15JK1620)

摘　　要：为了降低丝裂霉素C(MMC)在治疗翼状胬肉时经角膜吸收所导致的副作用,将其与DHA偶联为前药DHA-MMC。经离体角膜透过性实验及体外释放实验,结果发现:增大的相对分子质量可阻断MMC的角膜吸收,以避免其眼内副作用;MMC可以前药(DHA-MMC)形式积聚在眼表后逐渐释放MMC以产生活性。In order to reduce the side effects of mitomycin C （MMC） by corneal absorption in the treat- ment of pterygium,the prodrug DHA -MMC was preparaed by chemical coupling with DHA and MMC. The results of the corneal permeability experiment and in vitro release experiment showed that increased relative molecular weight could block MMC＇s corneal absorption, The prodrug DHA -MMC could amass in ocular surface and then so as to avoid its ocular side effects. release the MMC to generate activity.

关 键 词：DHA 前药 DHA-MMC 翼状胬肉 

分 类 号：TQ460.6[化学工程—制药化工]