替吉奥单药与替吉奥联合顺铂治疗老年晚期胃癌患者的疗效及安全性  

Efficacy and safety of tegafur versus tegafur plus cisplatin in elderly patients with advanced gastric cancer

作　　者：洪艳艳[1] 陈振东[1] 许苗苗[1] 

机构地区：[1]安徽医科大学第二附属医院肿瘤中心,合肥230601

出　　处：《中国肿瘤临床与康复》2017年第8期953-956,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨替吉奥单药与替吉奥联合顺铂治疗老年晚期胃癌患者的疗效及安全性。方法选取2012年1月至2014年7月间安徽医科大学第二附属医院收治的54例老年晚期胃癌患者,采用随机数表法分为单药组(S-1组)28例和联合化疗组(SP组)26例。S-1组患者采用替吉奥治疗,SP组患者采用顺铂联合替吉奥治疗。比较两组患者疗效和化疗后不良反应,采用Kaplan-Meier生存率曲线计算两组患者中位无进展生存时间(PFS)及总生存时间(OS)。结果两组近期疗效、客观缓解率(RR)和疾病控制率(DCR)比较,差异均无统计学意义(均P>0.05)。S-1组患者的中位OS和中位PFS分别为8.6个月和5.0个月,SP组分别为8.9个月及5.5个月,差异均无统计学意义(均P>0.05)。最常见的不良反应是血液学毒性和消化道反应,两组患者总体不良反应比较,差异无统计学意义(P>0.05),无化疗相关性死亡。结论替吉奥单药治疗老年晚期胃癌患者的近期疗效、生存率及安全性与替吉奥联合顺铂的疗效相当,可作为老年晚期胃癌患者的化疗选择。Objective To explore the efficacy and safety of tegafur versus tegafur plus cisplatin in elderly patients with advanced gastric cancer. Methods Fifty-four elderly patients （age〉 60 years） with advanced gastric cancer who were treated at The Second Affiliated Hospital of Anhui Medical University from January 2012 to July 2014 were randomly divided into single agent group （S-1 group, 28 patients） and com- bined chemotherapy group （SP group, 26 patients）. The S-1 group received chemotherapy with tegafur and the SP group was treated with tegafur at the same dose as S-1 group combined with cisplatin. Efficacy and adverse reactions after chemotherapy were compared between the two groups. Kaplan-Meier survival rate curve was used to calculate the median progression-free survival （PFS） and overall survival （OS） in the two groups. Results There was no significant difference in short-term response rate （RR） and disease control rate （DCR） between two groups （P 〉 0.05 ）. The median OS and median PFS was 8.6 months and 5.0 months, respectively for S-1 group and 8. 9 months and 5.5 months, respectively for SP group （P 〉 0.05 ）. The most common adverse reactions were hematologic toxicity and gastrointestinal reaction （P 〉 0. 05） and no chemotherapy related death was observed. Conclusion The short-term efficacy, survival rate and safety of single agent with tegafur are equivalent to the combination therapy of tegafur with cisplatin, which can be used as a choice regarding chemotherapy for elderly patients with advanced gastric cancer.

关 键 词：胃肿瘤 药物疗法 老年人 疗效 安全性 

分 类 号：R735.2[医药卫生—肿瘤]