肝门部胆管癌不同治疗方法的疗效  

Therapeutic effects of different treatments of hilar cholangiocarcinoma

作　　者：郝志强[1] 季德刚[1] 孟子辉[1] 郭镭[1] 李巍[1] 

机构地区：[1]吉林大学中日联谊医院肝胆胰外科,长春130033

出　　处：《中华肝胆外科杂志》2017年第8期517-520,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金（81273264）;吉林省科技厅国际科技合作项目（20160414022GH）

摘　　要：目的分析不同方法治疗肝门部胆管癌（HCCA）的临床疗效。方法分析吉林大学中日联谊医院收治的101例HCCA的临床资料，根据不同治疗方法分组，对比各组疗效的差异。结果根治性手术组患者（n=22）1年、2年总生存率分别为95．5％、40．9％，优于与姑息性手术组（n=24），两组差异有统计学意义（P〈0．05）。姑息性手术组患者1年、2年总生存率分别为75．0％和16．7％，优于PTCD组（n=26）、胆道支架组（n=16）和开腹外引流组（n=13），差异有统计学意义（P〈0．05）。PTCD组、胆道支架组及开腹外引流组患者的1年、2年总生存率差异无统计学意义（P〉0．05）。结论根治性切除术是HCCA最有效的治疗方法，其治疗效果明显优于姑息性手术、胆道支架和PTCD外引流治疗。Objective To analyze the clinical data of patients with hilar cholangiocarcinoma （ HCCA）, and to compare the therapeutic effects of different methods on treating these patients. Methods The clinical data of 101 patients with HCCA in China-Japan Union Hospital of Jilin University were ana- lyzed. Results The overall 1-year and 2-year survival rates in the radical operation group were 95.5% and 40.9% , respectively. There was a significant difference between the radical operation group and the pallia- tive resection group （ P 〈 0. 05 ）. The overall 1-year and 2-year survival rates in the palliative resection group were 75.0% and 16. 7%, respectively, which were much better than those in patients treated with PTCD, biliary stent on open abdominal biliary drainage （ P 〈 0.05 ）. There were no significant differences among the PTCD, biliary stent and open abdominal biliary drainage groups （P 〉 0.05）. Conclusions Radical HCCA resection is still the best and the first choice treatment for patients with HCCA. The therapeutic effects of radical operation were much better than those of palliative resection, biliary stent, PTCD and open abdominal biliary drainage.

关 键 词：肝门胆管癌 根治性手术 姑息性手术 经皮经肝穿刺胆道引流 胆道支架 

分 类 号：R735.8[医药卫生—肿瘤]