肺癌CT能谱成像:定量分析及与TTF-1和EGFR表达水平的相关性  

Study on lung cancer characteristics using energy spectrum CT imaging:quantitative parameters measurement and its correlation with the expression level of TTF-1 and EGFR

作　　者：周航[1] 武峰[1] 

机构地区：[1]湖北省襄阳市中心医院放射科(湖北文理学院附属医院),湖北441000

出　　处：《放射学实践》2017年第8期839-842,共4页Radiologic Practice

摘　　要：目的:探讨能谱CT成像相关参数在反映肺癌生物学特征中的作用。方法:搜集我院60例经病理证实的肺鳞癌和腺癌患者的病例资料,所有患者采用能谱模式行CT平扫和增强扫描,获得病灶的定量参数值,包括标准化碘浓度(NIC)、能谱曲线斜率(K)和钙含量。采用免疫组化法测量EGFR和TTF-1在癌细胞中的表达水平。结果:27例肺腺癌中EGFR表达阳性20例、阴性7例,阳性组和阴性组中NIC分别为0.27±0.16和0.15±0.10,K分别为2.04±0.17和1.79±0.25,两组间的差异均具有统计学意义(P<0.05)。33例肺鳞癌中EGFR表达阳性19例、阴性14例,阳性组和阴性组中NICs分别为0.30±0.18和0.16±0.04,K分别为2.75±1.10和2.06±0.38,病灶内钙含量分别为6.57±0.67和4.73±1.56,两组间的差异均具有统计学意义(P<0.05)。结论:能谱CT成像参数中标准化碘含量和曲线斜率(K)可反映肺癌病灶的血供情况及微血管密度,肺鳞癌中钙含量是反映肺鳞癌生长状态的参考指标。Objective：To explore the performance of quantitative parameters obtained in CT spectral imaging on re- flecting the biological characteristics of of lung cancer. Methods ： 60 patients with pathologically confirmed squamous cell car- cinomas （SCs） or adenocarcinomas （ACs） of lung underwent plain and enhanced CT scan using spectral imaging mode,and quantitative parameters of the cancer including normalized iodine concentration （NIC） ,slope of spectal curve （K） and calci- um content （CC） were measured. And expression level of TTF-1 and EGFR in cancer cells were detected using immunohis- tochemieal experiments. Results： Among the 27 cases with ACs,there were 20 cases in the EGFR positive group and 7 cases in the EGFR negative group,and the NIC and K of the two groups were 0. 272±0. 16 vs 0. 15±0. 10 and 2.04±0. 17 vs 1.79±0.25,respectively;statistically significant difference was observed between the two groups （P（0.05）. Among the 33 patients with SCs,there were 19 cases in the EGFR positive group and 14 cases in the negative group,and the NIC,K and CC in the two groups were 0. 30±0.18 vs 0.16±0. 04,2. 75±1.10 vs 2.06±0.38,and 6.57±0.67 vs 4.73±1.56,respectively;statistically significant differences were observed between the two groups （P〈 0. 05）. Conclusion： In the CT spectral imaging of lung cancer,NICs and slope of the spectral curve can reflect the microvessel density and blood supply of lung cancer,and the calcium content is a index to reflect the growth status of lung squamous cell carcinoma.

关 键 词：肺癌 体层摄影术 X线计算机 能谱成像 免疫组织化学检查 

分 类 号：R730.44[医药卫生—肿瘤] R734.2[医药卫生—临床医学]