缓释氟尿嘧啶植入剂在进展期胃癌术中应用观察  

Observation of the application of fluorouracil sustained release implant in advanced gastric cancer surgery

作　　者：刘建山[1] 白铁成[1] 卢荣增 

机构地区：[1]延安大学附属医院胃肠外科,716000

出　　处：《中国综合临床》2017年第7期659-663,共5页Clinical Medicine of China

摘　　要：近年来随着区域性化疗在进展期胃癌术中应用得到重视,人们对区域性化疗药-缓释氟尿嘧啶植入剂的研究逐渐增多.缓释氟尿嘧啶植入剂是利用高分子骨架和膜层技术与传统化疗药氟尿嘧啶相结合的新型制剂,术中直接将药粒植入病灶区域通过其缓释性和靶向性特点充分发挥氟尿嘧啶抗肿瘤作用,进而降低胃癌的局部复发和转移率,提高患者生存期.通过对近年来研究者对缓释氟尿嘧啶植入剂的研究从基础、药学和临床三个方面的综述,希望可以为其在临床应用和更深入研究提供参考.Objective In recent years,as people have attached importance to the application of regional chemotherapy in the surgery of advanced gastric cancer,the research of fluorouracil sustained release implant,a regional chemotherapeutic drug,is on the increase.Fluorouracil sustained release implant is a new anti-carcinogen combined with fluorouracil,a conventional chemotherapeutic drug,through polymeric scaffolds and rete technology.It can be implanted into cancerous lesion area,as its slow-releasing potential and targeting property will give full play to the antitumor effect of fluorouracil,which can decrease the rate of local recurrence and metastasis of gastric cancer and prolong the life span of the patients.Based on the study of the researches on fluorouracil sustained release implant,a summary was made from different perspectives： basic medicine,pharmacy and clinical medicine.It may have reference value for clinical application and further study.

关 键 词：缓释氟尿嘧啶植入剂 腹腔内化疗 进展期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]