小窝蛋白-1和血管内皮生长因子在膀胱尿路上皮癌中的表达及其临床意义  

Expression of Caveolin-1 and VEGF in Bladder Urothelial Carcinoma and its Clinical Significance

作　　者：董建国 江海波 任选义 陈静 代翠莲 

机构地区：[1]兰考第一医院,河南兰考475300 [2]开封市中心医院,河南开封475000

出　　处：《肿瘤学杂志》2017年第8期698-701,共4页Journal of Chinese Oncology

摘　　要：[目的]探讨小窝蛋白-1(caveolin-1)和血管内皮生长因子(VEGF)在膀胱尿路上皮癌(BUC)组织中的表达及其临床意义。[方法 ]应用免疫组织化学PV-6000法检测caveolin-1和VEGF在86例BUC和13例正常膀胱黏膜组织中的表达情况并分析其相关性。[结果]Caveolin-1和VEGF蛋白在正常膀胱黏膜呈低表达(8.7%和15.4%),在BUC组织呈高表达(59.6%和75.6%),差异均有统计学意义(P=0.003,P=0.017)。Caveolin-1在BUC组织的阳性表达率随着膀胱癌分级和分期的提高,其表达水平呈增高趋势,差异有统计学意义(P=0.005,P=0.002)。VEGF在BUC组织的阳性表达率随着BUC分级和分期的提高其表达水平亦增高,差异有统计学意义(P=0.006,P=0.002)。Caveolin-1和VEGF蛋白在BUC组织中的阳性表达呈正相关(r=0.245,P=0.023)。[结论]Caveolin-1和VEGF在BUC组织中高表达,可作为促进BUC发生和进展的标志物。[Objective] To investigate the expression and clinical significance of caveolin-1 and vascular endothelial cell growth factor（VEGF） in bladder urothelial carcinoma（BUC）. [Methods]The expression level of caveolin-1 and VEGF protein in 86 cases of BUC and 13 cases of normal bladder mucosa was detected by immunohistochemical PV-6000 method,and the correlation of caveolin-1 and VEGF expression with clinicopathological features of BUC was analyzed. [Results] The positive rate of caveolin-1 and VEGF protein in BUC（59.6% and 75.6%） was higher than that in normal bladder mucosa（8.7% and 15.4%;P=0.003 and P=0.017）. The positive expression of caveolin-1 in BUC was positively correlated with the histological grades and T stages（P =0.005,P =0.002）. The positive expression of VEGF in BUC was positively correlated with the histological grade and T stages（P=0.006,P=0.002）. The expression of caveolin-1 and VEGF protein was positively correlated with each other in BUC（r=0.245,P=0.023）. [Conclusion] Caveolin-1and VEGF are highly expressed in BUC, indicating that both caveolin-1 and VEGF may promote the carcinogenesis and progression of BUC.

关 键 词：小窝蛋白-1 血管内皮生长因子 膀胱上皮癌 组织学分级 临床分期 

分 类 号：R737.14[医药卫生—肿瘤]