大肠癌无创早期诊断的核酸检测技术研究进展  

Research Progress of Nucleic Acid Detection Techniques in Noninvasive Early Diagnosis of Colorectal Cancer

作　　者：曹卓一 邓九零 方明笋[2] 周小杰[2] 陈丽娟[3] 陈亮[2] 

机构地区：[1]宁波市北仑区第二人民医院,浙江宁波315809 [2]浙江中医药大学,浙江杭州310053 [3]杭州市余杭区第一人民医院,浙江杭州311100

出　　处：《肿瘤学杂志》2017年第8期707-710,共4页Journal of Chinese Oncology

基　　金：浙江省医药科技计划项目(2017KY565)

摘　　要：大肠癌无创早期诊断有利于提高患者的生存率和顺应性,对粪便和血液中人源核酸进行检测是大肠癌无创早期诊断的重要途径,具有高特异性、高灵敏度和适用于大规模人群筛查等优点。核酸检测技术包括DNA检测技术和RNA检测技术,全文就这两类核酸检测技术应用于大肠癌早期无创诊断的研究进展进行概述。Noninvasive early diagnosis of colorectal cancer is beneficial to improve the survival rate and compliance of patients. Detection of nucleic acid molecules in stool and blood is a noninvasive method for early diagnosis of colorectal cancer with the advantages of high specificity and high sensitivity,which can be used in population screening. This article reviews the research advances on detection techniques of nucleic acids,including DNA detection and RNA detection,and their applications in the future.

关 键 词：大肠癌 无创早期诊断 核酸检测 

分 类 号：R735.34[医药卫生—肿瘤]