多种血清肿瘤标志物联合检测对肺癌诊断的临床意义  

Clinical siginficanie of combined detection of serum tumor markers for lung cancer

作　　者：陈艳露[1] 张茹[1] 张艳果[1] 郭李娜[1] 

机构地区：[1]长治医学院附属和济医院检验科,山西长治046000

出　　处：《中国实用医刊》2017年第16期13-16,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清肿瘤标志物糖类抗原125（CA125）、细胞角蛋白21—1片段（CYFR21—1）、神经特异性烯醇化酶（NSE）、鳞状细胞抗原（SCC）、癌胚抗原（CEA）和肿瘤相关物质（TSGF）等联合检测在肺癌诊断中的应用价值。方法选取肺癌患者80例（按肺癌类型分为肺鳞癌、肺腺癌及小细胞肺癌三个亚组）、肺良性疾病患者54例及健康对照者52例，分别采用免疫化学发光法检测三组受试对象血清中上述6种肿瘤标志物含量并进行比较。结果肺癌组血清中CA125、CYFR21—1、NSE、CEA、SCC和TSGF含量均明显高于健康对照组，差异有统计学意义（P〈0.05）。CYFRA21-1和SCC浓度在肺鳞癌组中显著高于其他两组肺癌（P〈0．05，P〈0．01）；CEA和CAl25血清浓度在肺腺癌组中显著高于其他两组肺癌（P均〈0.01）；NSE浓度在小细胞肺癌组中明显高于其他两组肺癌（P〈0．05）；TSGF浓度在三组肺癌亚组中比较差异未见统计学意义（P〉0．05）。6种血清肿瘤标志物联合检测的敏感性与各单项检测比较差异均有统计学意义（P均〈0.01）。结论肿瘤标志物的联合检测在肺癌的诊断及病理分型中优于单项检测，有较高的临床应用价值。Objective To investigate the clinical significance of serum tumor markers drate antigen 125 （CA125）, cytokeratin 21-1 fragment （CYFR21-1）, nerve specific enolase carbohy- （NSE）, squamons cell antigen （ SCC）, carcinoembryonic antigen （CEA） and tumor related substances （TSGF） in the diagnosis of lung cancer. Methods Eighty patients with lung cancer [ divided into three subunits according to the type of lung cancer; lung squamous cell carcinoma group, lung adenocarcinoma group and small cell lung cancer （SCLC）group] , 54 patients with lung benign disease and 52 healthy controls were enrolled in this study. Immunofluorescence method was used to detect the expression of the above six tumor markers among the three groups, and their differences were compared. Results The levels of serum CA125, CYFR21-1, NSE, CEA, SCC and TSGF of patients with lung cancer were significantly higher than those of healthy controls （P 〈 0. 05）. CYFRA21-1 and SCC concentrations in lung squamous cell carcinoma group were significantly higher than thoseof the other two groups of lung cancer（ P 〈0. 05 and P 〈 0. 01 ）, serum concentrations of CEA and CA125 of lung adenocarcinoma group were significantly higher than those of the other two groups of lung cancer （P 〈 0. 01 ）, NSE concentration SCLC group was significantly higher than that of the other two groups of lung cancer （ P 〈 0. 05 ）, and TSGF concentration of the three subunits of lung cancer had no significant difference （P 〉 0.05）. The sensitivity of the combined detection of the six serum tumor markers was significantly different from that of each single item （all P 〈 0. 01 ）. Conclusions Combined detection of tumor markers in diagnosis of lung cancer and pathological typing is superior to the single detection, and has high clinical value.

关 键 词：肺癌 肿瘤标志物 诊断 免疫化学发光法 联合检测 

分 类 号：R730.43[医药卫生—肿瘤] R734.2[医药卫生—临床医学]