血清VEGF、TFF1、PG、EGF变化及其与胃溃疡病理过程的关系  

Changes of Serum VEGF, TFF1, PG, EGF and Their Relationship with Pathological Process of Gastric Ulcer

作　　者：周莲[1] 符明昌[1] 郑志昂[1] 

机构地区：[1]海南省第三人民医院,三亚572000

出　　处：《基因组学与应用生物学》2017年第8期3278-3284,共7页Genomics and Applied Biology

基　　金：海南省第三人民医院资助

摘　　要：本研究探讨血清中血管内皮生长因子(VEGF)、组织三叶因子(TFF1)、胃蛋白酶原(PG)、表皮生长因子(EGF)变化及其与胃溃疡临床特征及愈合的关系。应用ELISA法测定活动性胃溃疡(n=68)、浅表性胃炎(n=60)健康对照组(n=60)血清VEGF、TFF1、PG、EGF水平。胃溃疡组均给予雷贝拉唑三联方案治疗,治疗前后均行14C-尿素呼气试验,胃镜下观察胃溃疡患者病理特征。胃溃疡组血清PG水平高于浅表性胃炎组及对照组(p<0.05),而TFF1、VEGF、EGF水平低于浅表性胃炎组及对照组(p<0.05),浅表性胃炎组血清PG水平高于对照组(p<0.05)。胃溃疡患者治疗后愈合率为58.82%(40/68),HP根治率为76.47%(52/68)。治疗后胃溃疡组炎症活动性评分、粘膜炎症反应评分较治疗前明显下降,而溃疡直径较治疗前显著减少(p<0.05)。治疗后未愈合组血清PG水平高于愈合组(p<0.05),而TFF1、VEGF、EGF水平低于愈合组(p<0.05)。治疗后HP(+)组血清PG水平高于HP(-)组(p<0.05),而TFF1、VEGF、EGF水平低于HP(-)组(p<0.05)。经Pearson单因素分析显示,血清PG水平与炎症活动性评分、粘膜炎症反应评分及溃疡面积呈正相关(p<0.05),而TFF1、VEGF、EGF水平与炎症活动性评分、粘膜炎症反应评分及溃疡直径呈负相关(p<0.05)。血清VEGF、TFF1、PG、EGF变化及其与胃溃疡病理特征及愈合有密切的关系,可作为评价胃溃疡发生及预后的有效指标。The aim of research was to investigate the changes of vascular endothelial growth factor （VEGF）, tissue trefoil factor （TFF1）, pepsinogen （PG） and epidermal growth factor （EGF） in serum and their relationship with ulcer clinical characteristics and healing. The levels of VEGF, TFF1, PG and EGF in serum with active gastric ulcer （n=68）, superficial gastritis （n=60） and healthy control group （n=60） were measured by enzyme-linked immunosorbent assay （ELISA）. The rabbits in gastric ulcer group were treated with rabeprazole triple regimen. The 14C-urea breath test was performed before and after treatment and the pathological features of gastric ulcer patients were observed under gastroscope. The level of serum PG in gastric ulcer group was higher than that in superficial gastritis group and control group （p〈0.05）, while the levels of TFF1, VEGF and EGF were lower than those in superficial gastritis group and control group （p〈0.05）. The level of PG in serum of gastritis group was higher than that of control group （p 〈0.05）. The healing rate of patients with gastric ulcer was 58.82% （40/68） and the cure rate of HP was 76.47% （52/68）. After treatment, the inflammatory activity score and mucosal inflammatory response score of gastric ulcer group significantly decreased, and the diameter of ulcer significantly decreased （/9〈0.05）. The levels of serum PG in untreated group were higher than those in the healing group （p〈0.05）, but the levels ofTFF1, VEGF and EGF were lower than those in the healing group （/9〈0.05）. Moreover, the levels of serum PG in HP （＋） group were higher than that in HP （-） group （p〈0.05）, but the levels ofTFF1, VEGF and EGF were lower than those in HP （-） group. The level of PG in serum were positively correlated with inflammatory activity score, mucosal inflammatory reaction score and ulcer area （p〈0.05）, but the levels ofTFF1, VEGF and EGF were negatively correlated with inflammation activity scored b

关 键 词：血管内皮生长因子 组织三叶因子 胃蛋白酶原 表皮生长因子 胃溃疡临床特征 愈合 

分 类 号：R573.1[医药卫生—消化系统]