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作 者:刘又嘉[1] 贺璐[1] 郭艳芳[2] 谭周进[1]
机构地区:[1]湖南中医药大学微生物教研室,湖南省长沙市410208 [2]湖南中医药大学第一附属医院儿科,湖南省长沙市410007
出 处:《世界华人消化杂志》2017年第22期2007-2014,共8页World Chinese Journal of Digestology
基 金:国家自然科学基金资助项目;No.81573951~~
摘 要:梭菌(Clostridium)是肠道内一大类正常的兼性厌氧细菌,属于厚壁菌门,能产生芽孢.目前已经报道的梭菌有十几种,其中有一些主要用于疾病的预防、诊断或治疗,还有部分被证实与人类某些疾病的发生、发展、预后转归息息相关,比如抗生素相关性腹泻、伪膜性结肠炎等疾病.其主要包括有益的梭菌和有害的梭菌两大类,主要来源于肠道和粪便.本文总结了目前已报道的肠道梭菌种类、有害梭菌的致病机制及与药物疗效相关作用机制、益生梭菌的主要产物及基因的应用、微生态制剂研制等方面研究进展,为肠道梭菌在疾病预防和治疗方面的进一步研究提供思路与依据.Clostridium spp. belongs to firmicutes, which is a large class of normal facultative anaerobic bacteria in intestine and can produce spores.Dozens of Clostridium strains have been reported in previous studies. Some of them were used to prevent, diagnose and treat relative human diseases, and others were demonstrated to be related to diseases including antibioticassociated diarrhea, pseudomenbraneouscolitis and so on. Clostridium mainly derives from the intestinal tract and fecal matter and consists of two types: harmful and beneficial. This paper summarizes the Clostridium strains that have been found in former studies, the pathogenic mechanisms of harmful Clostridium and the therapeutic mechanisms of drugs for them,and the application of products and gene of beneficial Clostridium, with an aim to provide some clues to the prevention and treatment of diseases related to intestinal Clostridium.
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