Capn4和P52在结肠癌中的表达及意义  

Expression of Capn4 and P52 in colon cancer and its clinical significance

作　　者：王东华[1] 贾喜花[1] 郑淑君[1] 赵霞[1] 张丙信[1] 王晓博[1] 

机构地区：[1]保定市第一中心医院肿瘤内科,河北保定071000

出　　处：《现代医学》2017年第7期925-928,共4页Modern Medical Journal

摘　　要：目的:探讨钙蛋白酶小亚基-1(Capn4)和核转录因子-κB2(p52)在结肠癌中的表达及临床意义,以及两者在结肠癌发生、发展过程中的相关性。方法:应用免疫组织化学方法检测70例结肠癌组织及35例癌旁正常结肠组织中Capn 4和p52的表达情况,并分析Capn 4和p52的表达与结肠癌临床病理特征的关系。结果:Capn 4及p52在结肠癌(74.3%、70.0%)中的表达明显高于癌旁正常结肠组织(22.9%、31.4%)(P<0.05),两者在结肠癌组织中表达与结肠癌的浸润深度、TNM分期以及有无淋巴结转移密切相关(P<0.05),与患者年龄、性别、分化程度无关(P>0.05),并且两者在结肠癌的发生发展中可能存在相关性(r=0.869,P<0.05)。结论:Capn 4和p52在结肠癌组织中高表达,提示两者可能与结肠癌的浸润、转移有关。两者的表达呈正相关,提示Capn 4可能通过NF-κB通路的非经典途径起作用。Objective： To investigate the expression of calpain small subunit-1（ Capn4） and nuclear transcription factor-kappa B2（ p52） in colon cancer and its clinical significance. The correlation between Capn4 and p52 involving the development and progression of colon cancer is investigated. Methods： The expressions of Capn4 and p52 in seventy cases with colon cancer tissue and Thirty-five cases with normal colon mucosa tissueare detected by immunohistochemistry. And to analyze the relationship between the expression of them and clinicopathological features of colon cancer. Results： The expression of Capn4 and p52 in colon cancer tissue（ 74. 3%,70. 0%,respectively） is significantly higher than normal colon mucosa tissue（ 22. 9%,31,4%,respectively）（ P〈0. 05）.The expression of Capn4 and p52 is significantly correlated with depth of infiltration,TNM staging and lymph node metastasis（ P〈0. 05）,but there is not correlated with age,sex and differentiation grade of colon cancer（ P〈0. 05）. And the expression of Capn4 and p52 is positively correlated（ r = 0. 869,P〈0. 05）. Conclusion： In colon cancer,Capn4 and p52 are high-expression,suggesting that Capn4 and p52 may involve the development and progression of colon cancer. The expression of both is positive correlated,suggesting that Capn4 may play a role in colon cancer by non-canonical NF-kappa B signaling pathway.

关 键 词：Capn4 P52 结肠癌 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]