美多巴联合普拉克索对老年帕金森病患者非运动症状的疗效分析  

Impact of non-motor symptoms in old patients with parkin sons disease treated with madopar combined pramipexole

作　　者：尤汉生 毛秀琴[1] 石俊[1] 徐顺生[2] 

机构地区：[1]湖北省黄梅县人民医院神经内科,黄冈438000 [2]湖北省人民医院精神卫生中心

出　　处：《国际精神病学杂志》2017年第4期649-651,663,共4页Journal Of International Psychiatry

摘　　要：目的探索美多巴联合普拉克索对老年帕金森病患者非运动症状的治疗效果。方法选取2014年6月~2016年1月我院收治的72例老年帕金森病患者作为研究对象,随机分为对照组和研究组各36例。对照组患者单纯给予美多巴治疗,而研究组则在对照组的基础上给予普拉克索治疗。结果研究组患者治疗后的非运动症状问卷量表(NMSQuest)、汉密尔顿抑郁量表(HAMD)和匹兹堡睡眠质量指数量表(PQSI)评分分别为(14.28±1.96)分、(9.23±2.58)分和(4.46±1.24)分,显著低于对照组的(17.37±2.18)分、(12.56±3.05)分和(6.28±1.83)分,两组间差异有统计学意义(P<0.05);两组患者治疗后的简明精神状态量表(MMSE)和帕金森病自主神经症状量表(SCOPAAUT)评分比较,差异无统计学意义(P>0.05);研究组患者治疗后血清IL-1β和IL-6的水平分别为(10.54±1.43)pg/m L和(4.96±0.64)pg/L,显著低于对照组的(12.97±1.86)pg/m L和(8.75±1.22)pg/L,两组间差异有统计学意义(P<0.05);研究组患者不良反应的发生率为5.56%,低于对照组的13.89%,但差异无明显统计学差异(P>0.05)。结论美多巴联合普拉克索可有效改善老年帕金森病患者的非运动症状,降低IL-1β和IL-6的水平,安全有效,值得应用于临床。Objective To discuss the impact of non-motor symptoms in old patients with parkinson s disease treated with madopar combined pramipexole. Methods 72 old patients with parkinson s disease from June 2014 to January 2016 were randomly selected and divided into 36 patients of them treated wih madopar only were taken as control group,while the other 36 patients of them treated with madopar combined pramipexole were taken as research group. Results The scores of NMSQuest、HAMD and PQSI were（14.28±1.96）,（9.23±2.58）and（4.46±1.24）in research group after treatments,which were lower than that in control group（P〈0.05）. The scores of MMSE and SCOPA-AUT in two groups after treatments were without statistical significance（P〈0.05）. The levels of IL-1βand IL-6 were（10.54±1.43）pg/m L and（4.96±0.64）pg/L in research gorup after treatments,which were lower than that in control group（P〈0.05）. The occurrence rate of adverse reactions was 5.56% in research group,which is lower that in control group,but differences were without statistical significance（P〈0.05）. Conclusions Old patients with parkin son s disease in treatments of madopar combined pramipexole can improve non-motor symptoms and reduce the levels of IL-1βand IL-6 with effective and safety,which is worthy of clinical use.

关 键 词：美多巴 普拉克索 老年帕金森病 非运动症状 

分 类 号：R749.053[医药卫生—神经病学与精神病学]