替普瑞酮对慢性萎缩性胃炎转归的作用分析  

Analysis of the effect of teprenone on the outcomes of chronic atrophic gastritis

作　　者：陈得枝 张振辉 黎瑞怡 黄启聪 

机构地区：[1]广东东莞市中堂医院药剂科,523220

出　　处：《中国实用医药》2017年第20期98-100,共3页China Practical Medicine

摘　　要：目的分析替普瑞酮对慢性萎缩性胃炎转归的作用。方法 96例慢性萎缩性胃炎患者,随机分成对照组与观察组,各48例。对照组给予常规治疗,观察组在常规治疗基础上应用替普瑞酮治疗。比较两组的症状评分情况和临床治疗效果。结果治疗前两组患者的症状评分比较差异无统计学意义(P>0.05),治疗后观察组的症状评分(0.24±0.07)分,优于对照组的(1.21±0.12)分,差异有统计学意义(t=46.838,P<0.05)。观察组治疗总有效率为93.8%,明显高于对照组的66.7%,差异有统计学意义(P<0.05)。治疗后对两组幽门螺杆菌分别进行了检查,观察组与对照组的幽门螺杆菌转阴率分别为83.3%(40例)与79.2%(38例),两组比较差异无统计学意义(P>0.05)。结论替普瑞酮对慢性萎缩性胃炎转归的作用显著,可有效的改善患者的临床症状,抑制幽门螺杆菌,具有显著的治疗作用,值得在临床中广泛的应用。Objective To analyze the effect of teprenone on the outcomes of chronic atrophic gastritis. Methods A total of 96 chronic atrophic gastritis patients were randomly divided into control group and observation group, with 48 cases in each group. The control group received conventional therapy, and the observation group received teprenone on the basis of conventional therapy. Comparison were made on symptom score and clinical therapeutic effect in two groups. Results Before treatment, both groups had no statistically significant difference in symptom score （P〉0.05）. After treatment, the observation group had better symptom scoreas （0.24 ± 0.07） points than （1.21± 0.12） points in the control group, and the difference had statistical significance （t=46.838, P〈0.05）. The observation group had obviously higher total treatment effective rate as 93.8% than 66.7% in the control group, and the difference had statistical significance （P〈0.05）. After treatment, Helicobacter pylori in two groups were examined. The observation group and control group had Helicobacter pylori negative conversion rate respectively as 83.3% （40 cases） and 79.2% （38 cases）, and the difference had no statistical significance （P〉0.05）. Conclusion The effect of teprenone on the prognosis of chronic atrophic gastritis is remarkable. It can effectively improve the clinical symptoms of patients and inhibit the Helicobacter pylori, and it has a significant therapeutic effect. So it is worthy of extensive clinical application.

关 键 词：替普瑞酮 慢性萎缩性胃炎 转归作用 

分 类 号：R573.32[医药卫生—消化系统]