草酸艾司西酞普兰与盐酸舍曲林治疗首发伴焦虑症状抑郁症的疗效比较  

Comparison of efficacy of escitalopram oxalate and sertraline hydrochloride in the treatment of first-episode with anxiety symptoms depression

作　　者：杨银喜 

机构地区：[1]揭阳市人民医院,522000

出　　处：《中国实用医药》2017年第20期101-103,共3页China Practical Medicine

摘　　要：目的比较草酸艾司西酞普兰与盐酸舍曲林治疗首发伴焦虑症状抑郁症的疗效。方法 62例首发伴焦虑症状抑郁症患者,按入院的先后顺序分为观察组和对照组,各31例。对照组给予盐酸舍曲林治疗,观察组给予草酸艾司西酞普兰治疗。观察两组患者的治疗效果及不良反应情况。结果对照组总有效率为87.10%,观察组总有效率为90.32%,比较差异无统计学意义(P>0.05)。观察组心电图(ECG)异常、肝功能异常、头痛、恶心呕吐、静坐不能发生率(3.23%、0、9.68%、3.23%、3.23%)低于对照组(19.35%、19.35%、32.26%、19.35%、19.35%),差异均具有统计学意义(P<0.05)。两组嗜睡、便秘、失眠发生率比较,差异均无统计学意义(P>0.05)。结论草酸艾司西酞普兰与盐酸舍曲林治疗首发伴焦虑症状抑郁症的疗效相当,但草酸艾司西酞普兰的不良反应发生率较低,值得临床推广使用。Objective To compare the efficacy of escitalopram oxalate and sertraline hydrochloride in the treatment of first-episode with anxiety symptoms depression. Methods A total of 62 patients with first- episode with anxiety symptoms depression were divided by admission order into observation group and control group, with 31 cases in each group. The control group received sertraline hydrochloride for treatment, and the observation group received escitalopram oxalate for treatment. Observation were made on therapeutic effect and adverse reactions situation in two groups. Results The control group had total effective rate as 87.10%, and the observation group had total effective rate as 90.32%, and the difference had no statistical significance （P〉0.05）. The observation group had lower incidence of abnormal electrocardiogram （ECG）, abnormal liver function, headache, nausea and vomiting and akathisia （3.23%, 0, 9.68%, 3.23% and 3.23%） than the control group （19.35%, 19.35%, 32.26%, 19.35% and 19.35%）, and the difference had statistical significance （P〈0.05）. Both groups had no statistically significant difference in incidence of lethargy, constipation and insomnia （P〉0.05）. Conclusion Escitalopram oxalate and sertraline hydrochloride shows equal effect in the treatment of first-episode with anxiety symptoms depression, but the incidence of adverse reactions of eseitalopram oxalate is lower. So it is worthy of clinical promotion and use.

关 键 词：草酸艾司西酞普兰 盐酸舍曲林 伴焦虑症状抑郁症 

分 类 号：R749[医药卫生—神经病学与精神病学]