三阴性乳腺癌组织中肿瘤干细胞相关标记物CD44^+/CD24^(-/low)和ALDH1+的表达及意义  

The Expression and Significance of Tumor Stem Cell Marker CD44^+/CD24^(-/low) and ALDH1+ in Triple Negative Breast Cancer

作　　者：王安安[1] 吴恒宇[1] 刘磊[1] 罗永辉[1] 李里香[1] 

机构地区：[1]南昌大学第二附属医院,江西南昌330006

出　　处：《中国医学创新》2017年第25期23-27,共5页Medical Innovation of China

基　　金：江西省卫生计生委科技计划项目(20155287)

摘　　要：目的:探讨三阴性乳腺癌(TNBC)组织中乙醛脱氢酶1(aldehyde dehydrogenases l,ALDH1)和CD44^+/CD24^(-/low)的表达及其与临床预后的关系。方法:通过免疫组织化学SP法检测ALDH1和CD44^+/CD24^(-/low)等生物学指标在30例三阴性乳腺癌(TNBC)术后石蜡切片组织和30例非三阴性乳腺癌术后石蜡切片组织中的表达,并分析其与TNBC的临床预后因素的关系。结果:TNBC组织中ALDH1+表达率为46.67%,CD44^+/CD24^(-/low)阳性表达率为56.67%;非三阴性乳腺癌组织中ALDH1+表达率为16.67%,CD44^+/CD24^(-/low)阳性表达率为26.67%,TNBC组织中ALDH1和CD44^+/CD24^(-/low)阳性表达率明显高于非三阴性乳腺组织,两者比较差异有统计学意义(P<0.05)。腋窝淋巴结转移率在CD44^+/CD24^(-/low)与ALDH1均阳性表达组和非阳性表达组中分别为66.67%和23.81%(χ~2=4.983,P=0.035);局部复发和/或转移率分别为33.34%和0(χ~2=7.778,P=0.021)。结论:TNBC组织中ALDH1+和CD44^+/CD24^(-/low)过表达,可以作为判断TNBC患者预后的标记物。Objective： To investigate the expression and relationship with clinical prognosis of aldehyde dehydrogenase 1 （ ALDH1 ） and the CD44^＋/CD24^-/low in triple negative breast cancer （ TNBC ） organization.Method：. ALDHI and CD44^＋/CD24^-/low biologieal index was deteeted by immunohistochemical SP method in 30 cases of triple negative breast cancer （ TNBC ） postoperative paraffin tissue and 30 eases of non-triple negative breast cancer postoperative paraffin tissue, and its relationship with the clinical prognostic factors was analyzed.Result： The expression rate of ALDH1＋ in TNBC was 46.67% and in non-triple negative breast cancer tissue was 16.67% respectively, the expression rate of CD44^＋/CD24^-/low in TNBC was 56.67% and in non-triple negative breast cancer tissue was 26.67% respectively, the difference was statistically significant （ P〈0.05 ） .The positive expression rates of ALDHI and CD44^＋/CD24^-/low in TNBC tissue was signifieantly higher than in the non-triple negative breast cancer tissue.Axillary lymph node metastasis rate in CD44^＋/CD24^-/low and ALDH1 both positive expression group and the non positive expression group were 66.67% and 23.81% respectively （ χ^2=4.983, P=4.983 ） .Local recurrence and/or metastasis rates were 33.34% and 0 respectively （ χ^2=7.778, P=7.778 ） .Conclusion： Overexpression of ALDHI＋ and CD44^＋/CD24^-/low may be used as a marker for the prognosis of patients with TNBC subtype.

关 键 词：三阴性乳腺癌 ALDH1 CD44^+/CD24^-/low 预后 

分 类 号：R737.9[医药卫生—肿瘤]