磁共振功能成像DWI技术在家兔胰腺肿物模型鉴别中的应用价值  

Application value of magnetic resonance diffusion weighted imaging technology in identification of rabbit pancreatic tumor model

作　　者：郝利国[1] 崔红升[2] 孟鑫[2] 隋雪峰[2] 杨艳丹[2] 张广凤[2] 张淑丽[1] 王梓旭[1] 周蕾[1] 陈曲[1] 申洪远 黄钰[1] 

机构地区：[1]齐齐哈尔医学院医学技术学院影像设备与技术学教研室,黑龙江齐齐哈尔161000 [2]齐齐哈尔医学院附属第三医院MR室,黑龙江齐齐哈尔161000

出　　处：《重庆医学》2017年第24期3375-3377,3380,共4页Chongqing medicine

基　　金：黑龙江中医药中青年科技攻关项目(ZQG-077);齐齐哈尔市科学技术计划项目(SFGG-201624)

摘　　要：目的探讨磁共振分子功能成像DWI技术在动物模型胰腺癌与肿块型胰腺炎的鉴别中的应用价值。方法选取实验室内家兔胰头移植瘤模型、慢性肿块型胰腺炎模型、正常家兔各8只,对其进行磁共振弥散加权分子功能成像,b值为333、667、1 000s/mm^2,观察不同b值下胰腺癌模型、慢性炎性模型及正常兔胰腺区的表观弥散系数(ADC),并分析不同b值下胰腺癌模型、慢性炎性模型及正常兔胰腺区的ADC值及表观弥散系数差值(DADC)的变化情况,并观察各组织在分子扩散、组织灌注等方面中的差异。结果整个研究周期,胰头移植瘤模型死亡率为50%;肿块型胰腺炎模型和8只正常家兔均正常存活。相同b值下胰腺癌ADC值明显低于慢性炎症及正常胰腺区,随着b值的增大,各组织ADC值明显下降,b值为333s/mm^2时,各组织内ADC数值存在差异(F=6.662,P=0.014),组间两两比较,胰腺癌与胰腺炎(t=6.773,P=0.003),胰腺癌与正常胰腺(t=5.883,P=0.016),差异有统计学意义(P<0.05)。b值增大,DADC越小,不同b值时胰腺癌区与慢性炎症肿块区、胰腺癌区与正常胰头区各组织DADC值变化差异有统计学意义(P<0.05)。结论合理选择b值的分子功能成像DWI技术能够较好的鉴别胰腺癌与肿块型胰腺炎,可在动物胰头癌模型的评价中推广应用。Objective To explore the application value of magnetic resonance molecular functional imaging diffusion weighted imaging（DWI）in the identification of pancreatic carcinoma and mass-type pancreatitis of animal model.Methods Each 8cases of laboratory pancreatic head transplantation tumor model,chronic mass-type pancreatitis model and normal rabbits were selected and performed the MR DWI molecular functional imaging,the b values were 333,667,1 000s/mm^2 respectively.The apparent diffusion coefficients（ADC）of pancreatic carcinoma model,mass-type pancreatitis model and normal pancreas under different b values were observed.Then the change situation of ADC values of pancreatic carcinoma model,mass-type pancreatitis model and normal pancreas under different b values and difference of ADC（DADC）was analyzed.Moreover the differences in molecular diffusion,tissue perfusion among various groups were observed.Results Throughout the study period,the mortality rate of pancreatic head transplantation tumor model was 50%;the mass-type pancreatitis model and 8normal rabbits were normally survival.The ADC value of pancreatic carcinoma under the same b value was significantly lower than that of chronic inflammation and normal pancreas area.The ADC value in each group was decreased with the increase of b value,and there was significant difference in ADC value when the b value was 333s/mm^2（F=6.662,P=0.014）,in the pairwise comparison among groups,the difference between pancreatic cancer and pancreatitis（t=6.773,P=0.003）and between pancreatic cancer and normal pancreas（t=5.883,P=0.016）had statistical significance（P0.05）.The b value was increased,DADC was smaller,the difference change of DADC between pancreatic cancer area and chronic pancreatitis mass area,between pancreatic cancer area and normal pancreatic head area had statistical significance（P0.05）.Conclusion Rationally selecting the molecular functional imaging DWI technology of b value can better distinguish pancreatic cancer from mass-type pancrea

关 键 词：磁共振成像 胰腺肿瘤 胰腺炎 鉴别诊断 

分 类 号：R-332[医药卫生] R445.2R735.9