自噬-溶酶体途径与帕金森病关系的研究进展  

Research Progress of Relationship Between Autophagy-Lysosome Way and Parkinson's Disease

作　　者：余沛豪 马骏[1] 王述菊[1] 王中明[1] 王彬[1] 王琪[1] 

机构地区：[1]湖北中医药大学针灸骨伤学院,湖北武汉430065

出　　处：《辽宁中医杂志》2017年第8期1766-1769,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81403456;81473788);武汉市科学技术局高新技术产业科技创新团队计划项目(2014072704021262)

摘　　要：帕金森病(Parkinson's disease,PD)是一种严重危害中老年人健康的神经退行性疾病,其典型的病理特征为黑质多巴胺(DA)能神经元变性缺失和神经元包浆内嗜酸性包涵体路易小体(LB)的形成,LB是PD的诊断特征,α-突触核蛋白(α-syn)则是LB的主要结构成分,具有细胞毒性作用的α-syn通常表现为寡聚体和多聚体状态。研究表明,自噬-溶酶体途径是病理状态下清除异常聚集蛋白质更为有效的清除方式。文章就自噬-溶酶体途径与PD之间关系的研究进展作以下综述。Parkinson＇s disease is a neurodegenerative disease which seriously endangers the health of the middle-aged and the elderly. The typical pathological feature is degeneration and deletion of dopaminergic neurons in substantial nigra and the formation of neurons within the patina eosinophilic inclusion lewy bodies. LB is the diagnostic feature of PD,alpha-syn is the major structure of LB. Cytotoxic alpha-syn usually exhibits oligomeric and multimeric states. Studies have shown that the autophagy lysosomal pathway is a more effective way to remove aberrant aggregation proteins in pathological conditions. This article reviews the progress in the study of the relationship between autophagy lysosomal pathway and PD.

关 键 词：自噬-溶酶体途径 帕金森病 Α-突触核蛋白 

分 类 号：R742.5[医药卫生—神经病学与精神病学]