胃肠间质瘤术后154例预后分析  

Prognosis Analysis of 154 Cases of Gastrointestina1 Stromal Tumor

作　　者：雷程[1] 刘翔[2] 葛磊[1] 王琦三[1] 王海江[1] 

机构地区：[1]新疆医科大学附属肿瘤医院胃肠外科,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院日间病房,新疆乌鲁木齐830011

出　　处：《肿瘤基础与临床》2017年第4期300-303,共4页journal of basic and clinical oncology

基　　金：国家自然科学基金地区科学基金项目(编号:81560385)

摘　　要：目的探讨胃肠间质瘤(GIST)患者的长期生存情况,对其综合治疗效果进行评估。方法对新疆肿瘤医院胃肠外科2002年1月至2015年9月行手术治疗的154例GIST患者的临床病理资料进行回顾性分析,并随访。结果 154例患者术后随访1~156(41)个月,1、3、5、10 a生存率分别为98.5%、96.8%、81.1%、72.7%。高危GIST患者(102例)1、3、5、10 a生存率分别为98.1%、86.5%、77.8%、41.2%。中高危GIST患者中辅助治疗组(63例)与随访观察组(27例)5 a疾病无进展生存率分别为80.7%和48.7%,比较差异有统计学意义(χ~2=6.415,P=0.011);2组5 a生存率分别为89.0%和68.8%,比较差异无统计学意义(χ~2=0.646,P=0.421)。结论早期诊断、根治性切除以及术后规范的治疗随访是GIST患者获得长期生存的关键;对于术后复发转移的GIST患者,分子靶向药物联合外科手术治疗的综合治疗模式可使其获益并获得长期生存。Objective To investigate the long-term survival situation for gastrointestinal stromal tumors （GIST） and to assess the effect of comprehensive treatment. Methods The clinicopathological and follow-up data of 154 surgical patients with GIST treated at our department between January 2002 and September 2015 were retrospectively reviewed. Results All the 154 patients were followed up with a median time of 41 months （ 1 to156 months）. The 1-, 3-, 5-, and 10-year survival rate of all the 154 patients with GIST were 98.5%, 96.8%, 81.1% and 72.7%. The 1-, 3-, 5-, and 10-year survival rate of 102 patients with high risk GIST were 98.1%, 86.5%, 77.8% and 41.2%. In the patients with middle and high risk GIST, the 5-year progression free survival rate of the adjuvant treatment group and the follow-up observation group were 80.7% and 48.7% , respectively, there were significant differences （X2 = 6. 415, P = 0. 011 ）. However, the 5 year survival rates of the two groups were 89.0% and 68.8%, respectively, and the difference was not statistically significant （X2 = 0. 646, P = 0.421 ）. Conclusion Early diagnosis, radical resection, standard treatment and follow-up after resection are the keys to patients with GIST achieving long-term survival. The composite treatment that targeted therapy combining surgical intervention could benefit these patients who having recurrence and metastasis after resection.

关 键 词：胃肠间质瘤 外科手术 预后 

分 类 号：R735.2[医药卫生—肿瘤] R730.56[医药卫生—临床医学]