急性白血病化疗后合并结核感染临床分析  

Clinical Analysis of Acute Leukemia Complicated with Tuberculosis After Chemotherapy

作　　者：左文丽 邓梅 杨景柯 尹青松 朱兴虎 魏旭东 

机构地区：[1]郑州大学附属肿瘤医院血液科,河南郑州450008

出　　处：《肿瘤基础与临床》2017年第4期304-306,共3页journal of basic and clinical oncology

基　　金：国家自然基金资助项目(编号:81000921)

摘　　要：目的探讨急性白血病化疗后合并结核感染的临床特点、诊断、治疗和转归。方法回顾性分析了我院198例急性白血病患者中合并结核感染的4例患者的临床资料,并进行相关文献复习。结果 198例急性白血病患者中有4例(2.02%)合并结核感染,其中急性髓系白血病及急性淋巴细胞白血病各2例,均存在应用化疗药物及化疗后骨髓抑制期白细胞减少等易感因素,临床表现为发热、咳嗽等,给予抗结核治疗后,3例病情比较稳定,目前随访均处于完全缓解中,1例因白血病复发死亡。结论急性白血病化疗后易合并结核感染,发病率高于正常人群,其临床特点不典型,抗结核治疗后疗效确切,不影响患者的长期生存。Objective To investigate the clinical features, diagnosis, treatment and prognosis of tuberculosis in- fection in patients with acute leukemia after chemotherapy. Methods The clinical data of 4 patients complicated with tuberculosis after chemotherapy in the 198 patients with acute leukemia in our hospital were summarized and analyzed. Results Four patients complicated with tuberculosis after chemotherapy in the 198 patients with acute leukemia, including 2 patients with acute myeloid leukemia and 2 patients with acute lymphoblastic leukemia re- spectively （ accounted for 2.02% ）. There were some susceptible factors such as chemotherapy and myelosuppres- sion after the chemotherapy, the clinical manifestations were fever, cough and so on. Anti tuberculosis treatment was given, and 3 patients were stable and 1 patient died of leukemia recurrence. Conclusion Acute leukemia are sus- ceptible to complicated with tuberculosis after chemotherapy, the incidence rate is higher than the normal, the clini- cal features are atypical, the long term survival of the patients were not affected after correct and timely treatment of anti-tuberculosis.

关 键 词：急性白血病 化疗 结核 

分 类 号：R733.71[医药卫生—肿瘤] R521[医药卫生—临床医学]