大蒜素对豚鼠心房肌电生理的作用  

Effect of Allitridi on electrophysiological characteristic of guinea pig atrium muscles

作　　者：程伟[1] 喻荣辉[2] 屈松柏[1] 

机构地区：[1]湖北中医学院附属医院心内科,湖北武汉430061 [2]武汉市第一医院,湖北武汉430061

出　　处：《中国中医基础医学杂志》2002年第7期35-37,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：湖北省教委基金资助项目 (No .940 3 1)

摘　　要：To exploring the effect of Allitridi on anti arrhythmia, cardiac electrophysiological characteristic are detected in guinea pig atrium muscles by intracellular microelectrode technique. Result:The automaticity which adrenalin induces is inhibited at 125 and 625 umol/L. The force of contraction is weakened; the intensity time curve which reflects excitability move towards right after 625 umol/L administration. under 25、125、625 μmol/L, functional refractory period、action potential duration of 50% and 90% repolarization、 sinus cycle longness are extended, a relationship between dose and effect exist at SCL. Conclusion: Automaticity、 excitability and refractoriness not only are inhibited but also action potential durations are extended after Allitridi administration.To exploring the effect of Allitridi on anti arrhythmia, cardiac electrophysiological characteristic are detected in guinea pig atrium muscles by intracellular microelectrode technique. Result:The automaticity which adrenalin induces is inhibited at 125 and 625 umol/L. The force of contraction is weakened; the intensity time curve which reflects excitability move towards right after 625 umol/L administration. under 25、125、625 μmol/L, functional refractory period、action potential duration of 50% and 90% repolarization、 sinus cycle longness are extended, a relationship between dose and effect exist at SCL. Conclusion: Automaticity、 excitability and refractoriness not only are inhibited but also action potential durations are extended after Allitridi administration.

关 键 词：大蒜素 心房肌 动作电位 心肌电生理特性 动物实验 心律失常 

分 类 号：R285.5[医药卫生—中药学] R259.[医药卫生—中医学]