脑出血昏迷病人继发多器官功能障碍综合征的危险因素分析  

The risk factors analysis of the multiple organ dysfunction syndrome in patients with cerebral hemorrhage coma

作　　者：张成刚[1] 

机构地区：[1]安徽省滁州市第一人民医院神经内科,239000

出　　处：《蚌埠医学院学报》2017年第6期736-737,共2页Journal of Bengbu Medical College

摘　　要：目的:探讨脑出血昏迷病人继发多器官功能障碍综合征(MODS)危险因素,为临床治疗提供参考。方法:选取88例脑出血昏迷病人分为2组,A组为继发MODS 48例,B组为未继发MODS 40例。对2组白细胞介素(IL)-1、IL-10等指标进行检测,并进行格拉斯哥昏迷评分、急性生理与慢性健康状况(APACHE-Ⅱ)评分,检测MODS情况并分析危险因素。结果:A组病人IL-1、IL-10、APACHE-Ⅱ评分、脑出血量及血糖等指标均高于B组(P<0.05~P<0.01),而格拉斯哥昏迷评分低于B组(P<0.01);A组病人APACHE-Ⅱ评分、IL-10、血糖以及脑出血量均为MODS的主要危险因素(P<0.05~P<0.01)。结论:脑出血量、血清IL-10活性、APACHE-Ⅱ评分及血糖过高等因素是造成脑出血昏迷病人继发MODS的重要危险因素。Objective： To investigate the risk factors of the multiple organ dysfunction syndrome（ MODS） in patients with cerebral hemorrhage coma for providing a reference in clinical treatment. Methods： Eighty-eight patients with cerebral hemorrhage coma were divided into group A（ 48 cases with MODS） and group B（ 40 cases without MODS）. The levels of interleukin（ IL）-1 and IL-10 in two groups were detected. The scores of the Glasgow Coma Scale,acute physiology and chronic health evaluation（ APACHE-Ⅱ） in two groups were measured,and the risk factors of MODS were analyzed. Results： The levels of IL-1 and IL-10,APACHE-Ⅱ score,cerebral hemorrhage amount,blood glucose level and other indicators in group A were higher than those in group B（ P〈0. 05 to P〈0. 01）,and the score of Glasgow Coma Scale in group A was lower than that in group B（ P〈0. 01）. The APACHE-Ⅱ score,IL-10,blood glucose levels,and cerebral hemorrhage amount were the main risk factors of MODS（ P〈0. 05 to P〈0. 01）. Conclusions： The cerebral hemorrhage amount,IL-10 level,APACHE-Ⅱ score,and high blood glucose are the main risk factors of MODS in cerebral hemorrhage patients.

关 键 词：脑出血 昏迷 多器官功能障碍综合征 

分 类 号：R743.34[医药卫生—神经病学与精神病学]