HP联合血CEA、CA72—4、CA24—2对早期胃癌筛查的价值  

The value of HP combined with serum CEA, CA72-4 and CA24-2 in early gastric cancer screening

作　　者：安俊平[1] 刘彬[1] 师艾丽[1] 陈启龙[1] 

机构地区：[1]徐州市肿瘤医院消化科,徐州221002

出　　处：《中国医师杂志》2017年第8期1165-1167,1171,共4页Journal of Chinese Physician

基　　金：徐州市科技局项目（XZZD1342）

摘　　要：目的探讨幽门螺杆菌（Hp），血清癌胚抗原（CEA）、血清癌抗原72-4（CA72-4）、CA24-2联合检测在胃癌筛查中的价值。方法检测70例胃癌患者、45例胃良性病变患者、50例健康对照者Hp阳性率及血清中CEA、CA72-4、CA24—2水平。根据检测出的阳性例数，计算出单项检测的阳性率，联合检测的阳性率。血清肿瘤标记物和Hp单项及联合检测的敏感度、特异度和准确度。结果胃癌组各单项检测、4项联合检测的阳性率与胃良性病变组和正常对照组比较，差异均具有统计学意义（P〈0．01）。胃癌组4项联合检测的阳性率为81．42％，与单项检测比较差异具有统计学意义（P〈0．01）。胃良性组和正常对照组各单项检测及4项联合检测的阳性率比较，差异无统计学意义（P〉0．05）。Hp、血清CEA、CA72-4、CA24-2联合检测的敏感度，特异度及准确性明显高于单项检测（P〈0．05）。结论联合检测明显优于单项检测，能显著提高胃癌检出率。Objective To investigate the value of Helicobacter pylori （ HP）, blood carcinoembry- onic antigen （CEA）, carbohydrate antigens 72-4 （CA72-4） and CA24-2 in the screening of gastric cancer. Methods The contents of HP, blood CEA, CA724 and CA24-2 in 50 healthy controls, 45 patients with benign gastric lesions and 70 patients with gastric cancer were detected. According to the number of positive cases, the positive rate of single detection and the positive rate of combined detection were calculated. Sen- sitivity, specificity, and accuracy of serum tumor markers were calculated according to HP single and com- bined detection. Results The positive rate of each individual detection and 4 joint detection in gastric cancer group was significantly different from that in the benign lesion group and the normal control group （P 〈0. 01 ）. The positive rate of 4 joint detection in gastric cancer group was 89. 25%, and the difference was statistically significant （P 〈 0. 01 ）. There was no significant difference in the positive rate of the single test and the 4 joint detection in benign stomach group and normal control group （ P 〉 0. 05 ）. The sensitivity, specificity and accuracy of HP, blood CEA, CA724, CA24-2 joint detection were significantly higher than single detection （P 〈 0. 05）. Conclusions Joint detection was significantly better than single detec- tion, and can significantly improve the detection rate of gastric cancer.

关 键 词：螺杆菌 幽门 癌胚抗原 抗原 肿瘤相关 碳水化合物 胃肿瘤/诊断 

分 类 号：R735.2[医药卫生—肿瘤]