单唾液酸神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效分析  

Analysis on clinical efficacy of single sialic acid ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy

作　　者：刘玉兰[1] 

机构地区：[1]中山市黄圃人民医院儿科,528429

出　　处：《中国实用医药》2017年第21期102-104,共3页China Practical Medicine

摘　　要：目的分析单唾液酸神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)效果。方法 70例HIE新生儿,采用随机数字表法分为对照组和观察组,各35例。两组患儿均给予常规三项支持治疗等,观察组在此基础上联合单唾液酸神经节苷脂治疗。比较两组患儿治疗效果、新生儿20项行为神经评定(NBNA)评分、末次随访婴幼儿智能发育检查量表(CDCC)评分。结果观察组显效率为85.71%,高于对照组的60.00%,差异有统计学意义(P<0.05)。观察组随访(6.1±1.3)个月,对照组(6.0±1.5)个月。治疗第7、14天,两组患儿NBNA评分均高于治疗前,且观察组患儿高于对照组,差异具有统计学意义(P<0.05);两组末次随访CDCC评分比较差异无统计学意义(P>0.05)。结论单唾液酸神经节苷脂治疗新生儿HIE有助于神经功能恢复,改善颅脑灌注。Objective To analyze the effect of single sialic acid ganglioside in the treatment of neonatal hypoxic isehemic encephalopathy （HIE）. Methods A total of 70 HIE neonates were divided by random number table method into control group and observation group, with 35 cases in each group. Both groups received conventional three supportive treatment, and the observation group also received single sialic acid ganglioside for treatment. Comparison were made on therapeutic effect, twenty item neonatal behavioral neurological assessment （NBNA） scores and the final follow-up infant intelligence development scale of Children＇ s Developmental Center of China （CDCC） score in two groups. Results The observation group had higher effective rate as 85.71% than 60.00% in the control group, and the difference had statistical significance （P〈0.05）. The observation group was followed-up for （6.1 ± 1.3） months, and the control group was followed-up for （6.0 ± 1.5） months. After 7 and 14 d of treatment, both groups had higher NBNA score than before treatment, and the observation group was higher than the control group. Their difference had statistical significance （P〈0.05）. Both groups had no statistically significant difference in final follow-up CDCC score （P〉0.05）. Conclusion Single sialic acid ganglioside is helpful for the recovery of neurological function and the improvement of cerebral perfusion for the treatment of neonatal HIE.

关 键 词：新生儿 缺氧缺血性脑病 单唾液酸神经节苷脂 临床疗效 

分 类 号：R742[医药卫生—神经病学与精神病学]