乳腺癌中医证型与生物学指标相关性研究  

Study on the Correlation Between TCM Syndrome Types and Biological Indexes of Breast Cancer

作　　者：武瑞仙[1] 梁晨[1] 裴晓华[2] 周秉霞 李娟娟 

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学第三附属医院,北京100029 [3]山西省汾阳医院,山西汾阳032200 [4]桐乡市中医院,浙江桐乡314500

出　　处：《中医学报》2017年第8期1391-1393,共3页Acta Chinese Medicine

基　　金：北京中医药大学"重点学科"开放课题(2013-ZDXKKF-48)

摘　　要：目的:探讨乳腺癌中医辨证分型与生物学指标的相关性。方法:对364例乳腺癌患者进行术前辨证分型,术后收集免疫组化结果,探索证型与生物学指标是否相关。结果:364例患者中,肝郁痰凝证198例,占54.4%,冲任失调证150例,占41.2%,正虚毒炽证16例,占4.4%。正虚毒炽证ER、PR阴性率和p53、Ki-67阳性率高于肝郁痰凝证和冲任失调证,差异有统计学意义(P<0.0125),Cerb B-2表达与中医证型无相关性,差异无统计学意义(P>0.05)。结论:乳腺癌中医证型与生物学指标存在相关性,正虚毒炽证预后较差。Objective：To explore the relevance between traditional Chinese medicine syndrome differentiation of breast cancer andbiological indicators. Methods：364 cases of breast cancer patients with syndrome differentiation preoperative, collected postopera-tive immunohistoehemical results and explored if the syndrome was associated with biological indicator. Results ： In 364 cases of pa-tients ,there were 198 cases of stagnation of liver-Qi and phlegm, accounting for 54.4% , 150 cases of Chang Ren imbalance, ac-counting for 41.2%, 16 cases of Zheng deficiency and excessive poison, accounting for 4.4%. Negative rate of ER, PR and thepositive rate of p53, Ki-67 in type of Zheng deficiency and excessive poison were higher than stagnation of liver-Qi and phlegm andChang Ren imbalance, there was statistically significant difference （ P 〈 0. 012 5 ）, CerbB-2 expression and TCM syndrome typeshad no correlation, and there was no statistically significant difference （ P 〉 0.05 ）. Conclusion ： TCM syndrome types of breastcancer and biological indicators have correlation, Zheng deficiency and excessive poison type has poorer prognosis.Reference citation：WU Ruixian, LIANG Chen, PEI Xiaohua, et al. Study on the Correlation Between TCM Syndrome Types andBiological Indexes of Breast Cancer[ J]. Acta Chinese Medicine,2017,32（8） ：1391 - 1393.

关 键 词：乳腺癌 肿瘤 中医证型 生物学指标 

分 类 号：R273.79[医药卫生—中西医结合]