Optical coherence tomography and T cell gene expression analysis in patients with benign multiple sclerosis  

作　　者：John Soltys Qin Wang Yang Mao-Draayer 

机构地区：[1]University of Colorado Medical Scientist Training Program(MSTP),Aurora,CO,USA [2]Department of Neurology,University of Michigan Medical School,Ann Arbor,MI,USA

出　　处：《Neural Regeneration Research》2017年第8期1352-1356,共5页中国神经再生研究（英文版）

基　　金：funded by an investigator-initiated,unrestricted research grant(to YMD)from Biogen Idec.YMD served as a consultant and/or received grant support from:Acorda,Bayer Pharmaceutical,EMD Serono,Genzyme,Novartis,Questor,Teva Neuroscience and Chugai Pharma;supported by grants from NIH NIAID Autoimmune Center of Excellence:UM1-AI110557;NIH NINDS R01-NS080821,Novartis and Chugai(to YMD)

摘　　要：Benign multiple sclerosis is a retrospective diagnosis based primarily on a lack of motor symptom progression. Recent findings that suggest patients with benign multiple sclerosis experience non-motor symptoms highlight the need for a more prospective means to diagnose benign multiple sclerosis early in order to help direct patient care. In this study, we present optical coherence tomography and T cell neurotrophin gene analysis findings in a small number of patients with benign multiple sclerosis. Our results demonstrated that retinal nerve fiber layer was mildly thinned, and T cells had a distinct gene expression profile that included upregulation of interleukin 10 and leukemia inhibitory factor, downregulation of interleukin 6 and neurotensin high affinity receptor 1（a novel neurotrophin receptor）. These findings add evidence for further investigation into optical coherence tomography and m RNA profiling in larger cohorts as a potential means to diagnose benign multiple sclerosis in a more prospective manner.Benign multiple sclerosis is a retrospective diagnosis based primarily on a lack of motor symptom progression. Recent findings that suggest patients with benign multiple sclerosis experience non-motor symptoms highlight the need for a more prospective means to diagnose benign multiple sclerosis early in order to help direct patient care. In this study, we present optical coherence tomography and T cell neurotrophin gene analysis findings in a small number of patients with benign multiple sclerosis. Our results demonstrated that retinal nerve fiber layer was mildly thinned, and T cells had a distinct gene expression profile that included upregulation of interleukin 10 and leukemia inhibitory factor, downregulation of interleukin 6 and neurotensin high affinity receptor 1（a novel neurotrophin receptor）. These findings add evidence for further investigation into optical coherence tomography and m RNA profiling in larger cohorts as a potential means to diagnose benign multiple sclerosis in a more prospective manner.

关 键 词：neurotensin high affinity receptor 1 benign multiple sclerosis optical coherence tomography interleukin 10 T cell leukemia inhibitory factor optic neuritis neural regeneration 

分 类 号：R744.51[医药卫生—神经病学与精神病学]