溃疡性直肠炎患者血清中Resistin水平及其与CRP和IL-6的相关性研究  

Study on the relationship between serum Resistin and CRP,IL-6 in patients with ulcerative proctitis

作　　者：马娟[1] 莫波[1] 闵春明[1] 李晓雯[1] 

机构地区：[1]湖北医药学院附属人民医院肛肠外科,湖北十堰442000

出　　处：《解剖学研究》2017年第4期268-271,共4页Anatomy Research

摘　　要：目的探究溃疡性直肠炎患者血清中抵抗素(Resistin)的水平及其与C反应蛋白(CRP)、白介素-6(IL-6)的相关性。方法选取2014年9月-2015年9月收治我院经内镜证实的120例溃疡性直肠炎患者血清样本(试验组)和同期研究选取我院体检中心的120例健康体检者血清样本(对照组),并采用酶联免疫吸附(ELISA)检测患者血清中Resistin与CRP、IL-6的水平,分析指标间的相关性。结果与对照组相比,溃疡性直肠炎患者血清中Resistin,CRP,IL-6的水平明显升高(P<0.05),并且随着疾病病情严重程度的增加而升高;溃疡性直肠炎患者血清Resistin与CRP,IL-6呈相关(r=0.425,P=0.021;r=0.631,P=0.013)。结论溃疡性患者血清中Resistin的水平明显升高,并且与血清中CRP,IL-6和疾病病情的严重程度相关。指标的联合检测有利于对溃疡性直肠炎疾病病情的判断。Objective To investigate the level of resistin in patients with ulcerative proctitis and its correlation with C-reac- tive protein （CRP） and interleukin-6 （IL-6）. Methods A total of 120 patients with ulcerative proctitis in our hospital from Sep- tember 2014 to September 2015 were enrolled in this study. The serum samples of 120 healthy subjects were selected from the exper- imental group. The serum levels of Resistin, CRP and IL-6 were determined by enzyme-linked immunosorbent assay （ELISA）, and the correlation between them was analyzed. Results Compared with the control group, serum levels of Resistin, CRP and IL-6 in patients with ulcerative proetitis were significantly higher （P 〈0.05 ） and increased with the severity of ulcerative proctitis ; Serum re- sistin was correlated with CRP and IL-6 （r = 0.425, P = 0.021; r = 0.631, P = 0.013）. Conclusion Serum levels of Resistin were significantly elevated in patients with ulcerative disease and were associated with serum CRP, IL-6 and the severity of disease progression. The combination of indicators of ulcerative proctitis disease is conducive to the judgment of the disease.

关 键 词：溃疡性直肠炎 抵抗素 C反应蛋白 白介素-6 

分 类 号：R574.63[医药卫生—消化系统]