精神科1916例药品不良反应/事件分析  

Analysis of 1916 Cases of Psychiatry Adverse Drug Reaction/Events Reporting

作　　者：盛鑫[1] 叶明全[1] 童九翠[1,2] 杭荣华[1] 程旻[3] 

机构地区：[1]皖南医学院,安徽芜湖241002 [2]皖南医学院弋矶山医院临床药学部,安徽芜湖241001 [3]芜湖市第四人民医院,安徽芜湖241002

出　　处：《中国药物评价》2017年第4期305-308,共4页Chinese Journal of Drug Evaluation

基　　金：国家自然科学基金(61672386);教育部人文社会科学研究规划基金(16YJAZH071);安徽省自然科学基金(1708085MF142;1308085MH126)

摘　　要：目的:探讨精神科常用药品不良反应/事件(ADR/ADE)发生的特点与规律,为临床合理用药提供依据。方法:对芜湖市第四人民医院2012~2016年收集并上报的ADR/ADE报告1916例,按照性别与年龄、药品种类、累及系统-器官及临床表现、合并用药和转归情况进行统计分析。结果:1916例ADR/ADE报告中,18~30岁较多,584例(占30.50%);涉及药品29种,以抗精神病类药品引起ADR/ADE最多,报告1665例(占86.90%),ADR/ADE报告中药品奥氮平最多,820例(占49.24%);ADR/ADE累及系统为神经系统较多,701例(占35.67%)。结论:应继续加强精神科ADR/ADE的监测工作,通过对ADR/ADE的分析加强药品合理规范使用,为临床精神科医生用药提供参考。Objective：Exploring the characteristics and general pattern of the psychiatric adverse drug reaction/events （ADR/ADE） to provide scientific basis for clinical rational use of drugs. Methods ：1916 ADR/ADE cases collected in the 4th People＇s hospital of Wuhu from 2012 to 2016 were analyzed statistically in terms of patients＇ gender and age, drug category, involving system-organs, clinical mani- festations, drug combination and outcome. Results：Among 1916 cases of ADR/ADE reports, aged from 18 to 30 took up the highest pro- portion, around 584 cases （30. 50% ）. It＇s involving 29 kinds of drugs, ADR/ADE caused by antipsychotics were in the first place, ac- counting for 1665 cases （86. 90% ）, and olanzapine was the most commonly mentioned in reports, around 820 Cases （49. 24% ）. The most involved system of ADR/ADE was nervous system, 701 cases were reported （35.67%）. Conclusion： We should continue to strengthen the monitoring work of ADR/ADE, and regulate the rational use of drugs by analyzing ADR/ADE, which can provide refer- ences for clinical psychiatrists.

关 键 词：精神科用药 药物不良反应 药物分析 用药安全 

分 类 号：R95[医药卫生—药学]